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TranscriptomicsTranscript profiling of WT and Nxf2 KO post-natal day 21 testes
In euakryotes, mRNAs must be exported from the nucleus to the cytsoplasm. NXF2 is highly expressed in the mouse male germ cells. We are interested in its function in spermatogenesis, espically in the nuclear RNA export in the testis. To this end, we made Nxf2 mutant mice by gene targeting. In an att...
ORGANISM(S): Mus musculus 
2009-11-05 | GSE13526 | GEO
UnknownNXF2 is involved in cytoplasmic mRNA dynamics through interactions with motor proteins.
Not available
S-EPMC1885657 | biostudies-literature
UnknownInactivation of Nxf2 causes defects in male meiosis and age-dependent depletion of spermatogonia.
Not available
S-EPMC2702087 | biostudies-literature
TranscriptomicsTranscription profiling of mouse WT and Nxf2 KO post-natal day 21 testes
In euakryotes, mRNAs must be exported from the nucleus to the cytsoplasm. NXF2 is highly expressed in the mouse male germ cells. We are interested in its function in spermatogenesis, espically in the nuclear RNA export in the testis. To this end, we made Nxf2 mutant mice by gene targeting. In an at...
ORGANISM(S): Mus musculus 
2009-11-14 | E-GEOD-13526 | biostudies-arrayexpress
GenomicsDrosophila melanogaster
Drosophila melanogaster nxf2 knockdown
PRJNA606690 | ENA
ProteomicsA nuclear RNA export factor variant licenses piRNA-guided heterochromatin formation
Small RNA silencing pathways protect genome integrity in part through establishing heterochromatin at transposon loci. In animals, this process requires piRNA-guided targeting of nuclear PIWI proteins to nascent transcripts. The molecular events contributing to heterochromatin formation upon PIWI bi...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-06-12 | PXD011201 | Pride
Osc Silencio Panoramix Sfinx Nxf2 Nxt1 
GenomicsMus musculus
Transcript profiling of WT and Nxf2 KO post-natal day 21 testes
PRJNA110139 | ENA
ProteomicspiRNA-guided co-transcriptional silencing coopts nuclear export factors
The PIWI-interacting RNA (piRNA) pathway is a small RNA-based immune system that controls the expression of transposons and maintains genome integrity in animal germlines1,2. In Drosophila, piRNA-guided silencing is achieved, in part, via co-transcriptional repression of transposons by Piwi. This de...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-06-20 | PXD011415 | Pride
Pirna transposons piwi nuclear export 
TranscriptomicsNuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing
PIWI-interacting RNAs (piRNAs) are germline-specific small RNAs that form effector complexes with PIWI proteins (Piwi–piRISC complexes) to preserve genomic integrity by repressing transposable elements (TEs). Among PIWI-clade proteins in Drosophila, Piwi transcriptionally silences its targets via he...
ORGANISM(S): Drosophila melanogaster 
2019-07-09 | GSE131950 | GEO
GenomicspiRNA-guided co-transcriptional silencing coopts nuclear export factors
The PIWI-interacting RNA (piRNA) pathway is a small RNA-based immune system that controls the expression of transposons and maintains genome integrity in animal germlines1,2. In Drosophila, piRNA-guided silencing is achieved, in part, via co-transcriptional repression of transposons by Piwi. This de...
ORGANISM(S): Drosophila melanogaster 
2019-06-20 | GSE121661 | GEO
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