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UnknownSilencio/CG9754 connects the Piwi-piRNA complex to the cellular heterochromatin machinery.
Not available
S-EPMC4647559 | biostudies-literature
TranscriptomicsSilencio/CG9754 connects the Piwi-piRNA complex to the cellular heterochromatin machinery
The repression of transposable elements in eukaryotes often involves their transcriptional silencing via targeted chromatin modifications. In animal gonads, nuclear Argonaute proteins of the PIWI-clade complexed with small guide RNAs (piRNAs) serve as sequence specificity determinants in this proces...
ORGANISM(S): Drosophila melanogaster 
2015-11-19 | GSE74097 | GEO
GenomicsDrosophila melanogaster
Silencio/CG9754 connects the Piwi-piRNA complex to the cellular heterochromatin machinery
PRJNA299586 | ENA
UnknownPiwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells.
Not available
S-EPMC7732180 | biostudies-literature
TranscriptomicsPiwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells
Drosophila Piwi associates with PIWI-interacting RNAs (piRNAs) and represses transposons transcriptionally through heterochromatinization; however, this process is poorly understood. Here, we identify Brahma (Brm), the core adenosine triphosphatase of the SWI/SNF chromatin remodeling complex, as a n...
ORGANISM(S): Drosophila melanogaster 
2020-12-13 | GSE108329 | GEO
UnknownpiRNA-mediated regulation of transposon alternative splicing in the soma and germ line.
Not available
S-EPMC5933846 | biostudies-literature
GenomicspiRNA-mediated regulation of transposon alternative splicing in soma and germline
Transposable elements can drive genome evolution, but their enhanced activity is detrimental to the host and therefore must be tightly regulated. The piwi-interacting small RNAs (piRNAs) pathway is critically important for transposable element regulation, by inducing transcriptional silencing or pos...
ORGANISM(S): Drosophila melanogaster 
2017-12-06 | GSE103582 | GEO
ProteomicsA nuclear RNA export factor variant licenses piRNA-guided heterochromatin formation
Small RNA silencing pathways protect genome integrity in part through establishing heterochromatin at transposon loci. In animals, this process requires piRNA-guided targeting of nuclear PIWI proteins to nascent transcripts. The molecular events contributing to heterochromatin formation upon PIWI bi...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-06-12 | PXD011201 | Pride
Osc Silencio Panoramix Sfinx Nxf2 Nxt1 
GenomicsPiwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells
Piwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells
PRJNA423181 | ENA
GenomicsDrosophila melanogaster
piRNA-mediated regulation of transposon alternative splicing in soma and germline
PRJNA401989 | ENA
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