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ProteomicsThe dimeric SFiNX complex enables piRNA-guided co-transcriptional silencing through molecular condensate formation
Nuclear Argonaute proteins, guided by their bound small RNAs, orchestrate heterochromatin formation at transposon insertions and repetitive genomic loci. The molecular mechanisms that, besides recruiting heterochromatin effector proteins, are required for this silencing process are poorly understood...
ORGANISM(S): Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2021-02-12 | PXD022010 | Pride
Cut up/dlc8 Co-transcriptional gene silencing Dimerization Condensate formation Pirna pathway Sfinx 
GenomicsMolecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex
Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex
PRJNA668903 | ENA
UnknownMolecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex.
Not available
S-EPMC7919418 | biostudies-literature
GenomicsThe nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation
The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation
PRJNA493759 | ENA
UnknownThe nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.
Not available
S-EPMC6828549 | biostudies-literature
GenomicsMolecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex
Nuclear Argonaute proteins, guided by their bound small RNAs to nascent target transcripts, mediate cotranscriptional silencing of transposons and repetitive genomic loci through heterochromatin formation. The molecular mechanisms involved in this process are incompletely understood. Here, we show t...
ORGANISM(S): Drosophila melanogaster 
2020-12-31 | GSE159424 | GEO
TranscriptomicsThe nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation
The PIWI-interacting RNA (piRNA) pathway protects animal genome integrity in part through establishing repressive heterochromatin at transposon loci. Silencing requires piRNA- guided targeting of nuclear PIWI proteins to nascent transposon transcripts, yet the subsequent molecular events are not und...
ORGANISM(S): Drosophila melanogaster 
2019-04-17 | GSE120617 | GEO
ProteomicsA nuclear RNA export factor variant licenses piRNA-guided heterochromatin formation
Small RNA silencing pathways protect genome integrity in part through establishing heterochromatin at transposon loci. In animals, this process requires piRNA-guided targeting of nuclear PIWI proteins to nascent transcripts. The molecular events contributing to heterochromatin formation upon PIWI bi...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-06-12 | PXD011201 | Pride
Osc Silencio Panoramix Sfinx Nxf2 Nxt1 
GenomicsThe Piwi-piRNA complex initiates transposon silencing via transcription termination factors PNUTS and Senataxin
Transcriptional silencing of transposable elements (TEs) is guided by Piwi and PIWI-interacting RNAs (piRNAs) through the SFiNX complex to induce heterochromatin formation. We previously reported that members of the SFiNX complex can induce TE silencing prior to heterochromatin formation, suggesting...
ORGANISM(S): Drosophila melanogaster 
2025-10-28 | GSE293712 | GEO
UnknownThree-point bending behavior of individual ZnO nanowires studied by <i>in situ</i> Laue microdiffraction.
Not available
S-EPMC12321028 | biostudies-literature
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