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ProteomicsO-GlcNAc pattern of sOGT regulates its substrate selectivity and function
O-GlcNAcylation occurs on thousands of proteins involved in various cellular events. O-GlcNAc transferase (OGT), one of the enzymes responsible for protein O-GlcNAcylation, is known to be auto-O-GlcNAcylated at multiple sites. However, the role of O-GlcNAcylation on OGT is still unknown. Here, we re...
ORGANISM(S): Homo sapiens (Human) 
2019-09-16 | PXD009731 | Pride
O-glcnac pattern sogt site mapping functional regulation 
ProteomicsO-GlcNAc pattern of sOGT regulates its substrate selectivity and function
O-GlcNAcylation occurs on thousands of proteins involved in various cellular events. O-GlcNAc transferase (OGT), one of the enzymes responsible for protein O-GlcNAcylation, is known to be auto-O-GlcNAcylated at multiple sites. However, the role of O-GlcNAcylation on OGT is still unknown. Here, we re...
ORGANISM(S): Homo sapiens (Human) 
2019-09-16 | PXD010173 | Pride
O-glcnac pattern sogt site mapping functional regulation 
TranscriptomicsEffects of O-GlcNAc modification on gene expression using O-GlcNAcase deleted Mouse Embryonic Fibroblast cells.
Single O-GlcNAc modification orchestrate by O-GlcNAc Transferase (OGT) and O-GlcNAcase (OGA alias MGEA5) enzymes, affects signal transduction and gene expression by chromatin modulation. We developed Oga deleted MEF (mouse embryonic fibroblast) cells to investigate effects of O-GlcNAc modification i...
ORGANISM(S): Mus musculus 
2014-12-29 | GSE52721 | GEO
UnknownDisruption of O-GlcNAc cycling by deletion of O-GlcNAcase (Oga/Mgea5) changed gene expression pattern in mouse embryonic fibroblast (MEF) cells.
Not available
S-EPMC4583686 | biostudies-literature
ProteomicsMice kidney cortex proteome
O-GlcNAcylation is a global post translational modification. The purpose of this study is to investigate the role of O-GlcNAcylation in mice kidney proximal tubules. We used drug-inducible proximal tubular cells specific O-GlcNAc transferase (Ogt) KO mice (PTEC-Ogt KO). In this proteomic analysis, w...
ORGANISM(S): Mus Musculus (mouse) 
2019-05-17 | PXD012456 | JPOST Repository
TranscriptomicsGlycosylation regulates the stability of c-MYC
Tumorigenesis is characterised by changes in transcriptional regulation and the androgen receptor (AR) has been identified as a key driver in prostate cancer. In this study, we show that the hexosamine biosynthetic pathway (HBP) genes are overexpressed in clinical prostate cancer and androgen-regula...
ORGANISM(S): Homo sapiens 
2013-05-30 | E-GEOD-44624 | biostudies-arrayexpress
GenomicsMus musculus
Effects of O-GlcNAc modification on gene expression using O-GlcNAcase deleted Mouse Embryonic Fibroblast cells.
PRJNA229894 | ENA
ProteomicsO-GlcNAcylation in mitochondrial protein in rat astrocytes
To further investigate this idea that O-GlcNAcylation in mitochondria can improve the efficacy and benefit of mitochondrial transfer, we asked what mitochondrial proteins were modified with O-GlcNAc. To identify O-GlcNAcylated proteins and the potential target sites of O-GlcNAcylation, rat astrocyte...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-10-20 | PXD045316 | Pride
Astrocytes O-glcnacylation Mitochondria 
ProteomicsDifferentially O-GlcNAcylated proteins and sites in Y.pestis
Differentially O-GlcNAcylated proteins and sites in Y. pestis strains under Fv and Mh.
ORGANISM(S): Yersinia Pestis Co92 
2023-06-12 | PXD042927 |
ProteomicsDifferentially expressed proteins between WT Y. pestis and ΔhmwC
Differentially expressed proteins between WT Y. pestis and ΔhmwC
ORGANISM(S): Yersinia Pestis Co92 
2023-06-12 | PXD042928 |
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