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ProteomicsN-glycopeptide Signatures in Liver Diseases
(1) A N-glycopeptide method based on 18O/16O C-terminal labelling to obtain comparisons of serum from patients with HBV-related hepatocellular carcinoma (HCC-O18 labelling) and HBV-related liver cirrhosis (LC-O16 labelling) (2) MRM verification of N-glycopeptide alterations
ORGANISM(S): Homo Sapiens 
2019-09-10 | PXD013586 |
TranscriptomicsGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the hostM-bM-^@M-^Ys inflammatory response to the pathogen represents a potential tool to improve upon current diagno...
ORGANISM(S): Mus musculus 
2013-01-11 | E-GEOD-33341 | biostudies-arrayexpress
ProteomicsProteomic analysis of S-nitrosylated nuclear proteins in rat cortical neurons
S-nitrosothiol Resin Assisted Capture(SNORAC) coupled with mass spectrometry analysis has been used to study S-nitrosylated proteins in rat cortical neurons. Proteins were captured on the resin by covalently attaching their former S-NO moiety. Then, nistrosylated proteins were eluted by on-bead dige...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-07-11 | PXD009071 | Pride
Rat S-nitrosylation Cortical neurons Q-exactive 
ProteomicsMicrodissected pyramidal cell proteomics of Alzheimer brain reveals alterations in Creatine Kinase B, 14-3-3-g and Heat Shock Cognate 71
Novel insights on proteins involved in Alzheimer disease (AD) are needed. Since multiple cell types and matrix components are altered in AD, bulk analysis of brain tissue may be difficult to interpret. In the current study, we isolated pyramidal cells from the CA1 region of the hippocampus from five...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028282 | Pride
Quantitative ms Alzheimer disease Q exactive Homo sapiens O18 labelling 
ProteomicsA Proteomic Atlas of Atherosclerosis: Regional Proteomic Signatures for Plaque Inflammation and Calcification
Background: Using proteomics, we strove to reveal novel molecular subtypes of human atherosclerotic lesions, study their associations with histology and imaging and relate them to long-term cardiovascular outcomes. Methods: 219 samples were obtained from 120 patients undergoing carotid endarterectom...
ORGANISM(S): Homo sapiens (Human) 
2023-11-15 | PXD031052 | Pride
Calcification Tmt-labelling Plaque Cardiovascular outcome prognosis Atherosclerosis Inflammation Carotid endarterectomy 
ProteomicsCellular and extracellular proteomic profiling of paradoxical low-flow lowgradient aortic stenosis myocardium
Aims: Patients with severe aortic stenosis (AS), low transvalvular flow (LF) and low gradient (LG) with normal ejection fraction (EF)are referred to as paradoxical LF-LG AS (PLF-LG). PLF-LG patients develop more advanced heart failure symptoms and have a worse prognosis than patients with normal EF ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-30 | PXD055391 | Pride
Myocardial biopsies Transcatheter aortic valve implantation (tavi) Cellular and extracellular matrix proteomics Normal ejection fraction highgradient aortic stenosis Paradoxical low-flow low-gradient aortic stenosis 
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