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ProteomicsInability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders
The BAF complex modulates chromatin accessibility. Specific BAF configurations have functional consequences, and subunit switches are essential for cell differentiation. ARID1B and its paralog ARID1A encode for mutually exclusive BAF subunits. De novo ARID1B haploinsufficient mutations cause a neuro...
ORGANISM(S): Homo sapiens (Human) 
2021-10-12 | PXD028557 | Pride
Cncc Arid1a Arid1b Ip Baf Lc-ms/ms 
ProteomicsA PP2A-Integrator complex fine-tunes transcription by opposing CDK9
In this study, we discovered that CDK9-mediated, RNAPII-driven transcription is functionally opposed by a protein phosphatase 2A (PP2A) complex that is recruited to transcription sites by the Integrator complex subunit INTS6. PP2A dynamically antagonises phosphorylation of key CDK9 substrates includ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD025060 | Pride
Human Transcription Integrator Pp2a 
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