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TranscriptomicsGlobal transcriptomic profiling of oxygen-glucose deprivation (OGD)-mediated neuronal injury
Oxygen-glucose deprivation (OGD) is a cellular phenomenon consistently observed upon occurrence of ischemic stroke which eventually results in neuronal death. Neuronal cell death after ischemia takes place via two distinct processes, necrosis and apoptosis. Apoptosis, programmed cell death, is denot...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-23158 | biostudies-arrayexpress
GenomicsPHD inhibition upregulates glycolytic pathway in OGD
PHD inhibition upregulates glycolytic pathway in OGD
PRJNA534084 | ENA
TranscriptomicsTime resolved ribosome profiling study of oxygen and glucose deprivation of rat pheochromocytoma cells
Oxygen and glucose metabolism plays a pivotal role in many (patho)physiological conditions. In particular, oxygen and glucose deprivation (OGD) occurs during ischemia and stroke, resulting in extensive tissue injury and cell death. We applied time-resolved ribosome profiling technique to assess earl...
ORGANISM(S): Rattus norvegicus 
2015-04-10 | E-GEOD-60752 | biostudies-arrayexpress
ProteomicsCharacterization of secretomes from brain microvascular endothelial cells after ischemia
The human immortalized brain endothelial cell line hCMEC/D3 is considered an in vitro model of the blood-brain-barrier. We aimed to characterize changes in the secretome of hCMEC/D3 subjected to oxygen and glucose deprivation (OGD) by SILAC, in order to identify new proteins involved in ischemia-tri...
ORGANISM(S): Homo sapiens (Human) 
2016-01-21 | PXD002292 | Pride
Hcmec/d3 Endothelial cells Oxygen and glucose deprivation Silac Secretome 
GenomicsTranscriptomic study of the HT22 cells after OGD treatment.
Transcriptomic study of the HT22 cells after OGD treatment.
PRJNA741816 | ENA
TranscriptomicsPHD inhibition upregulates glycolytic pathway in OGD
To elucidate the mechanism of enarodustat pretreatment-induced protection against oxygen-glucose deprivation (OGD), we have we have employed whole genome microarray expression profiling as a discovery platform to identify genes upregulated by enarodustat exposure. HK2 cells were pretreated with eith...
ORGANISM(S): Homo sapiens 
2020-04-14 | GSE130144 | GEO
TranscriptomicsIn vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons.
The present study has used whole-rat genome microarray expression profiling to identify genes whose expression is significantly altered in hippocampal neuronal cultures submitted to oxygen and glucose deprivation (OGD), an established in vitro model for cerebral global ischemia that is suitable for ...
ORGANISM(S): Rattus norvegicus 
2014-06-16 | E-GEOD-54037 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of control and ischemic samples in vitro and in vivo
miRNA microarray profiling of primary cortical neurons exposed to 4h oxygen and glucose deprivation (OGD) in vitro. RNA samples collected at 8h post-OGD terminaion. miRNAs were also profiled in mice exposed to 3- vessel occlusion model of stroke. RNA samples collected from contralateral (control) a...
ORGANISM(S): Rattus norvegicus 
2013-11-21 | E-GEOD-51586 | biostudies-arrayexpress
GenomicsRNA‑seq transcriptomic analysis of HL‑1 cardiomyocytes under OGD/R injury with or without Phillyrin treatment
RNA‑seq transcriptomic analysis of HL‑1 cardiomyocytes under OGD/R injury with or without Phillyrin treatment
PRJNA1470647 | ENA
ProteomicsProteomic analysis identifies the potential effects of trichostatin A and bone marrow-derived dendritic cells on NIH3T3 cells under oxygen–glucose deprivation conditions
Fibroblasts usually mediate acute wound healing and long-term tissue remodeling with scarring in tissue injury. In myocardial infarction (MI), following a prolonged lack of oxygen supply, necrotized cardiomyocytes become replaced by secreted extracellular matrix proteins produced by fibroblasts. Den...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD021469 | Pride
Tsa  bmdcs  nih3t3 cells  fatty acid metabolism 
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