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ProteomicsAlterations of Ceramide Synthesis Induce PD-L1 Internalization and Signaling to Regulate Tumor Metastasis and Immunotherapy Response
Programmed death-ligand 1, PD-L1 (CD274) facilitates immune evasion and exerts pro-survival functions in cancer cells. Here, we report a new mechanism whereby internalization of PD-L1 in response to alterations of bioactive lipid/ceramide metabolism by ceramide synthase 4 (CerS4) induces sonic-hedge...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD053108 | Pride
Sonic-hedgehog Ceramide Sphingolipid Cers4 Pd-l1 Metastasis Immunotherapy 
ProteomicsOpportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors
Mechanisms by which Porphyromonas gingivalis (P. gingivalis) infection enhances oral tumor growth or resistance to cell death remain elusive. Here, we determined that P. gingivalis infection mediates therapeutic resistance via inhibiting lethal mitophagy in cancer cells and tumors. Mechanistically, ...
ORGANISM(S): Porphyromonas gingivalis Homo sapiens (Human) 
2024-06-23 | PXD051568 | Pride
Therapeutic resistance Oral cancers Ceramide  ceramide-dependent mitophagy  sphingolipid metabolism  oral infection  oral microbiota 
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