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Inducing mitochondrial uncoupling (mUncoupling) is an attractive therapeutic strategy for treating metabolic diseases because it leads to calorie-wasting by reducing the efficiency of oxidative phosphorylation (OXPHOS) in mitochondria. Here we report a safe mUncoupler, OPC-163493, which has unique p...
2019-05-24 | MTBLS836 | MetaboLights
Arabidopsis ABA hypersensitive germination2-1 mutant shows an enhanced sensitivity to ABA. This mutant has higher levels of endogenous ABA. This mutant also exhibited SA hypersensitivity and dwarf phenotype. Regarding SA hypersensitivity, ahg2-1 exhibits higher endogenous SA level and an enhanced re...
ORGANISM(S): Arabidopsis thaliana 
The purpose of this experiment was to compare the gene expression pattern between wild-type and Trib1-deficient macrophages in response to LPS. Experiment Overall Design: Two samples to define LPS-inducible gene and 4 samples (2 for wild-type and the rests for Trib1-deficient mice) for comparison.
ORGANISM(S): Mus musculus 
Many studies have reported on beneficial aspects of running to improve hippocampus-related spatial memory and promote neuroplastic changes like adult hippocampal neurogenesis (AHN). Such research has also revealed molecular factors associated with molecular signaling by BDNF and IGF-I leading to CRE...
ORGANISM(S): Rattus norvegicus 
Astaxanthin (ASX), the most powerful antioxidant within carotenoids, has not only anti-oxidative stress and anti-infammation, but also neuroprotective effects in the preventatin of oxidative damage on various neurodegenerative diseases in vivo and in vitro. Recent studies demonstrated that ASX enhan...
ORGANISM(S): Mus musculus 
To examine methylation profile of the CpG promoters in clinical sample of GISTs.
ORGANISM(S): Homo sapiens 
To reveal comprehensive gene expression profiles and their characteristics of the rice egg and synergid cell, we performed cell type-specific microarray analysis using nonenzymatic cell isolation technique. 40 and 50 genes expressed specifically in the egg cell and synergid cell were identified by c...
ORGANISM(S): Oryza sativa 
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