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ProteomicsIdentification of Missing Proteins in Human Olfactory Epithelial Tissue by Liquid Chromatography-Tandem Mass Spectrometry
We performed proteomic analyses of human olfactory epithelial tissue to identify missing proteins using liquid chromatography-tandem mass spectrometry. Using a next-generation proteomic pipeline with a <1.0% false discovery rate at the peptide and protein levels, we identified 3,731 proteins, among ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-12 | MSV000086444 | MassIVE
ProteomicsIdentification of Missing Proteins in Human Olfactory Epithelial Tissue by Liquid Chromatography-Tandem Mass Spectrometry
We performed proteomic analyses of human olfactory epithelial tissue to identify missing proteins using liquid chromatography-tandem mass spectrometry. Using a next-generation proteomic pipeline with a <1.0% false discovery rate at the peptide and protein levels, we identified 3,731 proteins, among ...
ORGANISM(S): Homo sapiens (Human) 
2018-08-17 | PXD010025 | Pride
Human Olfactory epithelial tissue Missing protein Lc-ms/ms 
TranscriptomicsThe human nose harbours a niche of olfactory ecto-mesenchymal stem cells displaying neurogenic and osteogenic properties
We previously identified multipotent stem cells within the lamina propria of the human olfactory mucosa, located in the nasal cavity. We also demonstrated that this cell type differentiates into neural cells and improves locomotor behavior after transplantation in a rat model of Parkinson’s diseas...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-24598 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat nasal respiratory and olfactory epithelium
The nasal epithelium is an important target site for chemically-induced toxicity and carcinogenicity. Human epidemiological investigations and experimental laboratory animal studies show that the nasal olfactory epithelium is selectively damaged by inhalation exposure to several chemicals, includin...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5019 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse olfactory epithelium to determine the identity of genes regulated at 3 d post-olfactory bulbectomy in the olfactory mucosa of carrier-injected Ccl3-/- mice compared with carrier-injected C57BL/6 mice
The aim was to determine the identity of genes regulated at 3 d post-olfactory bulbectomy in the olfactory mucosa of carrier-injected Ccl3-/- mice compared with carrier-injected C57BL/6 mice. Total RNA from the OE was hybridized to Affymetrix microarrays. A number of chemokine-, cytokine-, and gro...
ORGANISM(S): Mus musculus 
2007-10-13 | E-GEOD-1680 | biostudies-arrayexpress
TranscriptomicsExpression data from Emx2 wildtype and knockout olfactory epithelium
Emx2 is a homeobox transcription factor that plays a critical role in development. Olfactory sensory neuron axons from Emx2 knockout mice fail to innervate their target tissue, the olfactory bulb. Homeobox transcription factors may also play an important role in olfactory receptor expression. We use...
ORGANISM(S): Mus musculus 
2008-10-15 | E-GEOD-12135 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of the murine olfactory receptor neuron transcriptome
The recent development of next-generation sequencing (NGS) techniques encouraged us to assess the transcriptome of the murine OE. We analyzed RNA from OEs of female and male adult mice and from fluorescence-activated cell sorting (FACS)-sorted olfactory receptor neurons (ORNs) obtained from transgen...
ORGANISM(S): Mus musculus 
2015-01-21 | E-GEOD-53793 | biostudies-arrayexpress
TranscriptomicsGene Level Expression Profiling: Activity dependent genes in the olfactory epithelium
Gene level analysis of RNA samples from mice olfactory epithelium Gene expression profiling in the olfactory epithelium was performed to obtain a better understanding of the processes mediating activity dependent gene regulation We analyzed total RNA from olfactory epithelium tissue from 3 mice at 5...
ORGANISM(S): Mus musculus 
2014-04-21 | E-GEOD-49998 | biostudies-arrayexpress
TranscriptomicsGene Expression Analysis of Fezf1 Mutant Main Olfactory Epithelium
Mice lacking the transcription factor Fezf1 exhibit defects in the structural and molecular organiztion of their olfactory system. To invetigate this at the level of gene expression, we isolated Fezf1 expressing cells by FACS from the MOE of Fezf1+/- or Fezf1-/- animals and compared their gene expre...
ORGANISM(S): Mus musculus 
2011-05-27 | E-GEOD-26064 | biostudies-arrayexpress
TranscriptomicsExon Level Expression Profiling: Induced adult neurogenesis in the olfactory epithelium
Transcriptome analysis of RNA samples from mice olfactory epithelium Gene expression profiling in the olfactory epithelium was performed to obtain a better understanding of the processes mediating cell replacement. We analyzed epitheliual tissue from 3 adult male mice at 5 days following ipsilatera...
ORGANISM(S): Mus musculus 
2013-04-11 | E-GEOD-45931 | biostudies-arrayexpress
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