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ProteomicsRapid differentiation of hiPSCs into functional oligodendrocytes using an OLIG2 synthetic modified messenger RNARapid differentiation of hiPSCs into functional oligodendrocytes using an OLIG2 synthetic modified messenger RNA
We show that a synthetic modified messenger RNA (smRNA)-based reprogramming method that leads to the generation of transgene-free OLs has been developed. An smRNA encoding a modified form of OLIG2, a key TF in OL development, in which the serine 147 phosphorylation site is replaced with alanine, OLI...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD036975 | Pride
Olig2  synthetic modified messenger rna (smrna)  human pluripotent stem cells (hipscs)  oligodendrocytes  cell transplantation 
TranscriptomicsDevelopment of the prethalamus is crucial for thalamocortical projection formationand is regulated by Olig2
Thalamocortical axons pass through the prethalamus in the first step of their neural circuit formation Although it has been supposed that the prethalamus is an intermediate target for thalamocortical projection formation, much less is known about the molecular mechanisms of this targeting. The samp...
ORGANISM(S): Mus musculus 
2014-06-04 | E-GEOD-56389 | biostudies-arrayexpress
GenomicsActivation of the chromatin-remodeling factor Smarca4/Brg1 cooperates with Olig2 to establish oligodendrocyte identity and control CNS myelination [ChIP-seq]
We investigate the role of Brg1 and Olig2 during oligodendrocyte differentiation by combining gene conditional knockout and next generation sequencing technology. We generate genome-wide maps of RNA polymerase II (RPolII), Brg1 (Smarca4), Olig2 and histone modifications in primary rat oligodendrocyt...
ORGANISM(S): Rattus norvegicus 
2013-01-20 | E-GEOD-42447 | biostudies-arrayexpress
GenomicsComprehensive Identification of Long Non-coding RNAs in Purified Cell Types from the Brain Reveals Functional LncRNA in OPC Fate Determination (OLIG2 Chromatin immunoprecipitation sequencing (ChIP-Seq) in mouse neural stem cells)
To better understand the OLIG2 binding site in the whole-genome of mouse neural stem cells, ChIP was performed using 107 mouse neural stem cells. The ChIP-Seq library was constructed by using DNA SMART ChIP-Seq Kit according to the manufacturer's instructions (Clontech) and was sequenced on the Illu...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-74646 | biostudies-arrayexpress
TranscriptomicsComparison of polysomal profiles of murine adult normal, tumor, and recruited olig2 cells
Comparison of polysomal profiles of murine adult olig2 cortical progenitors, murine tumor olig2 cells derived from hPDGF-B-driven glioblastomas, and murine olig2 proliferative recruited glioma cells contributing to the tumor mass but not derived from the cell of origin An unbiased way to define a c...
ORGANISM(S): Mus musculus 
2011-06-17 | E-GEOD-30016 | biostudies-arrayexpress
ProteomicsThe INO80 chromatin remodeling complex regulates histone H2A.Z mobility and the G1-S transition in oligodendrocyte precursors
This project explores the role of the chromatin remodelling complex in oligodendrogial development using a series of tools including conditional disruption of the INO80 gene within mice and primary oligodendrocyte precursors. This experiment sought to understand whether INO80 complex proteins inter...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD056438 | Pride
Ino80  oligodendrocytes  h2a.z  chromatin remodelling complex  olig2 
TranscriptomicsmRNAseq analysis of Nkx2.2, Nkx6.1, and Olig2 overexpression in neural progenitors
Nkx2.2, Nkx6.1, and Olig2 repressors were overexpressed, singly or in combination, in in vitro-derived mouse neural progenitors to identify thier repression targets Overexpression study to identify genes repressed by Nkx2.2, Nkx6.1, and Olig2 in neural progenitors
ORGANISM(S): Mus musculus 
2015-08-24 | E-GEOD-65457 | biostudies-arrayexpress
GenomicsGenome-wide analysis of Olig2-positive and Olig2-negative tumors in a glioma mouse model.
Genome-wide analysis of Olig2-positive and Olig2-negative tumors in a glioma mouse model.
PRJNA432662 | ENA
GenomicsTranscriptome of nkx2.2a(+), olig2(+), dbx1b(+) cells from 14hpf zebrafish embryo
Transcriptome of nkx2.2a(+), olig2(+), dbx1b(+) cells from 14hpf zebrafish embryo
PRJNA647599 | ENA
GenomicsGenome-wide maps in PDGFB-induced glioma
We performed genome-wide profiling of oligodendrocyte lineage transcription factor 2 (Olig2) and other histone markers in platelet-derived growth factor subunit B (PDGFB)-induced glioma and genome-occupancy analyses coupled with transcriptome profiling to reveal gene regulatory network. Examination ...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-80088 | biostudies-arrayexpress
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