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ProteomicsThe role of testosterone in spermatogenesis: lessons from proteome profiling of human spermatozoa in testosterone deficiency
Testosterone is essential to maintain qualitative spermatogenesis. Nonetheless, no studies have been yet performed in humans to analyze the testosterone-mediated expression of the sperm proteins and their importance in reproduction. Thus, this study aimed to identify sperm protein alterations in mal...
ORGANISM(S): Homo sapiens (Human) 
2022-05-09 | PXD032270 | Pride
Proteomics Hypogonadism Tmt Lh deficiency Male infertility Sperm Testosterone 
ProteomicsStable-protein Pair Analysis as A Novel Strategy to Identify Proteomic Signatures: Application to Seminal Plasma From Infertile Patients.
Our aim was to define seminal plasma proteome signatures of infertile patients categorized according to their seminal parameters using TMT-LC-MS/MS. To that extent, quantitative proteomic data was analyzed following two complementary strategies: (i) the conventional approach based on standard statis...
ORGANISM(S): Homo sapiens (Human) 
2019-02-25 | PXD010579 | Pride
Proteomics Tmt Seminal plasma Male infertility Stable-protein pairs 
TranscriptomicsDifferential RNAs in the sperm cells of asthenozoospermic patients
Alterations in the presence of sperm RNAs have been identified using microarrays in teratozoospermic (abnormal morphology) or other types of infertile patients. However, so far no studies had been reported on the sperm RNA content using microarrays in asthenozoospermic patients (low motility). We st...
ORGANISM(S): Homo sapiens 
2012-03-15 | E-GEOD-34514 | biostudies-arrayexpress
ProteomicsCharacterization of human sperm protamine proteoforms through a combination of top-down and bottom-up mass spectrometry approaches
Protamine 1 (P1) and protamine 2 family (P2) are the most abundant nuclear basic spermspecific proteins, packing 85-95% of the paternal DNA. P1 is synthesized as a mature form, whereas P2 components (HP2, HP3 and HP4) arise from the proteolysis of the precursor (pre-P2). Due to the particular protam...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD014618 | Pride
Protamines  sperm  post-translational modifications  phosphorylation  nonannotated proteins  male infertility. Top-down proteomics  bottom-up proteomics  proteoforms  electron transfer dissociation 
ProteomicsProteomic changes in human sperm during sequential in vitro capacitation and acrosome reaction.
The male gamete is not completely mature after ejaculation and requires further events in the female genital tract to acquire fertilizing ability, including the processes of capacitation and acrosome reaction. In order to shed light on dynamic protein changes experienced by the sperm cell in prepara...
ORGANISM(S): Homo sapiens (Human) 
2019-12-17 | PXD014871 | Pride
Acrosome reaction Proteomics Mass spectrometry Tmt labeling Sperm Capacitation Spermatozoa 
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