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TranscriptomicsGene expression modulation by paraquat-induced oxidative stress conditions in P. brasiliensis
Paracoccidioides brasiliensis is a thermodimorphic fungus associated with paracoccidioidomycosis (PCM), the most common systemic mycosis in Latin America. The infection is initiated by inhalation of environmental dispersed conidia produced by the saprophytic phase of the fungus. In the lungs, P. bra...
ORGANISM(S): Paracoccidioides brasiliensis 
2013-06-14 | E-GEOD-41148 | biostudies-arrayexpress
TranscriptomicsSignaling pathways in skeletal muscle of Amyotrophic Lateral Sclerosis mouse model
Gene expression analyses through cDNA microarray of fifteen gastrocnemius muscles from transgenic and wild-type SOD1G93A mouse model by the ages of 40 and 80 days old were performed. We used a customized cDNA array containing the cDNA platform comprised of 2352 spots, 326 of them orthologous to mous...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-40328 | biostudies-arrayexpress
TranscriptomicsPerception of fight outcome is needed to activate socially driven changes in brain transcriptome
Group living animals must be able to express different behavior profiles depending on their social status. This implies that the same genotype may translate into different behavioral phenotypes through socially driven differential gene expression. Here we show for the first time that what triggers t...
ORGANISM(S): Danio rerio 
2014-04-10 | E-GEOD-56549 | biostudies-arrayexpress
GenomicsRif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead to loss of genetic information and chromosome rearrangements. The DNA repair protein p53 binding protein 1 (53BP1) protects the genome by limiting nucleolytic processing of DSBs by a mechanism that requires its ph...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-42298 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in Xylella fastidiosa 9a5c during co-cultivation with the endophytic bacteria Methylobacterium mesophilicum SR1.6/6
Citrus variegated chlorosis (CVC), caused by Xylella fastidiosa, is an important citrus disease that produces chlorotic injuries on leaves and reduced fruit size. This bacterium colonizes plant xylem, thereby interrupting sap flow. Other disease symptoms depend on environmental factors, since asympt...
ORGANISM(S): Xylella fastidiosa 
2014-04-18 | E-GEOD-56901 | biostudies-arrayexpress
MetabolomicsUntargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

INTRODUCTION: Interesting data about the family Asteraceae as a new source of Leishmania major dihydroorotate dehydrogenase (LmDHODH) inhibitors are presented. This key macromolecular target for parasites causing neglected diseases catalyzes the fourth reaction of the de novo pyr...

2019-10-14 | MTBLS722 | MetaboLights
ProteomicsHuman holo-transferrin glycation
Understanding the effect of glycation on the function of transferrin, the systemic iron transporter, is fundamental to fully grasp the mechanisms leading to the loss of iron homeostasis observed in diabetes mellitus (DM). The spontaneous reaction with protein amino groups is one of the main causes o...
ORGANISM(S): Homo sapiens (Human) 
2018-05-30 | PXD009345 | Pride
Post-translational modification Holo-transferrin Blood serum Glycation Lc-ms/ms 
TranscriptomicsGlobal modulation of gene expression in Paracoccidioides brasiliensis in response to thioridazine
Phenothiazines are antipsychotic drugs used in the treatment of schizophrenia, which have been shown to present antimicrobial activity (in vitro and in vivo) against a great variety of pathogenic microorganisms, including bacteria, parasites (protozoa and helmints) and fungi. In this study, we used ...
ORGANISM(S): Paracoccidioides brasiliensis 
2013-12-31 | E-GEOD-41881 | biostudies-arrayexpress
GenomicsRPA accumulation during class switch recombination represents 5'-3' DNA end resection during the S-G2/M phase of the cell cycle
AID promotes chromosomal translocations by inducing DNA double-strand breaks (DSBs) at immunoglobulin (Ig) genes and oncogenes in G1. RPA is a ssDNA-binding protein that associates with resected DSBs in the S phase and facilitates the assembly of factors involved in homologous repair (HR) such as R...
ORGANISM(S): Mus musculus 
2013-01-02 | E-GEOD-42451 | biostudies-arrayexpress
UnknownGuanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection.
Not available
S-EPMC6326519 | biostudies-literature
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