Sort   by:  
 Page size 
ProteomicsIdentification of Putative Kidney-Derived Proteins in Plasma using Nanoparticle Enrichment
Many diseases, including diabetes and hypertension, can lead to kidney damage, often resulting in long-term health complications and organ failure. Both animal and human studies have documented a causal relationship between high dietary sodium intake and elevated blood pressure. We explored a proteo...
ORGANISM(S): Papio hamadryas 
2026-03-30 | PXD071248 | Pride
Lc-msms Plasma Tissue-leakage proteins Diet challenge Kidney Baboon Non-human primates Sodium Nanoparticle affinity enrichment 
ProteomicsAn isobaric labeling approach to enhance detection and quan-tification of tissue-derived plasma proteins as potential early disease biomarkers
Accurate detection and quantification of low abundance proteins by standard mass spectrometry approaches remains challenging. In addition, it is difficult to link low abundance plasma proteins back to their specific tissues or organs of origin with confidence. To address these challenges, we develop...
ORGANISM(S): Papio anubis anubis Papio hamadryas adenovirus 1 
2023-03-11 | PXD039430 | Pride
Lc-msms Kidney Tmt Plasma 
ProteomicsHigh Density Lipoprotein Proteome in Non-alcoholic Fatty Liver Disease Patients
Characterization of HDL proteome in patients diagnosed with non-alcoholic fatty liver disease and to evaluate the impact on HDL function.
ORGANISM(S): Homo sapiens (Human) 
2018-09-13 | PXD005847 | Pride
Hdl Obesity Nafld Lc-ms/ms 
Transcriptomicsexpression profiling data of CLB-GA neuroblastoma cells upon TAE-684, Crizotinib, X-396, LDK378, Trametinib, BEZ-235 and Vandetanib
Treatment of the CLB-GA cell line with complementary ALK, MEK, PI3K/mTOR or RET inhibitors (and DMSO (VWR) as control) was performed in duplicate for each drug using the GI50 concentrations (see further): 0.5M-k_M Crizotinib (Pfizer/Sigma-Aldrich); 0.06M-k_M X-396 (VWR); 0.2M-k_M LDK378 (Hoelzel Bio...
ORGANISM(S): homo sapiens 
2015-05-04 | E-MTAB-3206 | biostudies-arrayexpress
TranscriptomicsmRNA expression profiles of SK-N-AS neuroblastoma cells with induced ALK-wt, ALK-F1174L or ALK-R1275Q
Establishment of inducible SK-N-AS ALKwt, ALKF1174L and ALKR1275Q cell lines Human neuroblastoma SK-N-AS cells were electroporated with pcDNA6/TR (Invitrogen) using the NeonM-eM-( Transfection System (Life Techologies). Single cell clones were generated using blasticidin (7.5M-eM-5g/ml) and limited ...
ORGANISM(S): homo sapiens 
2015-05-04 | E-MTAB-3207 | biostudies-arrayexpress
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
TranscriptomicsmRNA expression profiles of TAE-684 treated or shALK transfected neuroblastoma cell lines
Human wild-type ALK (SK-N-AS, NGP, IMR-32), ALKR1275Q (CLB-GA, LAN-5, UKF-NB-3), ALKF1174L (SK-N-SH, Kelly, SMS-KCNR) and ALK amplified (NB-1) neuroblastoma cell lines were treated in triplicate with 0.3M-k_M NPV-TAE-684 (Novartis/SelleckChem) or DMSO (VWR) for 6 hours, followed by RNA isolation and...
ORGANISM(S): Homo Sapiens 
2015-05-04 | E-MTAB-3205 | biostudies-arrayexpress
TranscriptomicsGlobal genomic mapping, in Saccharomyces cerevisiae, of new suppressor alleles of the RNA polymerase I subunit rpa49 deletion.
In the yeast saccharoryces cerevisiae, RPA49 full-deletion mutants show a strong growth defect at 30°C and are unable to grow at 25°C. However, spontaneous suppressors that restore growth at 25°C are observed. We attend to identified new suppressor alleles after UV treatment. To mapped the genomic l...
ORGANISM(S): Saccharomyces cerevisiae 
2019-12-31 | E-MTAB-7831 | biostudies-arrayexpress
UnknownExploration of Fluorinated Pyrazolidine-3,5-Diones for Positron Emission Tomography Imaging of the P2Y<sub>12</sub> Receptor in the Central Nervous System.
Not available
S-EPMC12444843 | biostudies-literature
TranscriptomicsInsights into Dahl salt-sensitive hypertension revealed
The results of this study identified a number of pathways potentially important for the amelioration of hypertension and renal injury in SS-13BN/Mcw rats, and these results generated a series of testable hypotheses related to the role of the renal medulla in the complex mechanism of salt-sensitive h...
ORGANISM(S): Rattus norvegicus 
2010-06-30 | E-GEOD-3588 | biostudies-arrayexpress
Sort   by:  
 Page size