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UnknownExtensive Molecular and Clinical Heterogeneity in Patients With Histologically Diagnosed CNS-PNET Treated as a Single Entity: A Report From the Children's Oncology Group Randomized ACNS0332 Trial.
Not available
S-EPMC9153369 | biostudies-literature
GenomicsApplication of Microdroplet PCR for Large-Scale Targeted Bisulfite Sequencing
Cytosine methylation of DNA CpG dinucleotides in gene promoters is an epigenetic modification that regulates gene transcription. While many methods exist to interrogate methylation states, no current methods offer large-scale, targeted, single CpG resolution. We report an approach combining bisulf...
ORGANISM(S): Homo sapiens 
2011-06-25 | E-GEOD-30179 | biostudies-arrayexpress
UnknownMED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver.
Not available
S-EPMC4287978 | biostudies-literature
UnknownAssessment of Subcutaneous vs Intravenous Administration of Anti-PD-1 Antibody PF-06801591 in Patients With Advanced Solid Tumors: A Phase 1 Dose-Escalation Trial.
Not available
S-EPMC6547134 | biostudies-literature
UnknownAssociation of Tumor Mutational Burden and Immune Gene Expression with Response to PD-1 Blockade by Sasanlimab Across Tumor Types and Routes of Administration.
Not available
S-EPMC8613140 | biostudies-literature
ProteomicsThe BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase
Strong associations exist between branched chain amino acids (BCAA) and dysregulated glucose and lipid metabolism, but the underlying mechanisms are not well understood. Here we report that inhibition of the kinase (BDK) or overexpression of the phosphatase (PPM1K) that regulate branched-chain keto...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-05-18 | PXD009122 | Pride
Ppm1k Acl Bdk Protein phosphorylation Bcaa 
UnknownMRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer.
Not available
S-EPMC10618744 | biostudies-literature
UnknownAcquired Resistance to KRASG12C Inhibition in Cancer.
Not available
S-EPMC8864540 | biostudies-literature
UnknownThe KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.
Not available
S-EPMC6954325 | biostudies-literature
UnknownComparison of hematopoietic cell transplant conditioning regimens for hemophagocytic lymphohistiocytosis disorders.
Not available
S-EPMC8821728 | biostudies-literature
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