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Proteomicsβ-catenin-controlled tubular cell-derived exosomes play a key role in fibroblast activation via the OPN-CD44 axis
Tubular injury and peripheral fibroblast activation are the hallmarks of chronic kidney disease (CKD) and renal fibrosis, suggesting intimate communication between the two diseases. However, the underlying mechanisms remain to be determined. Exosomes play a role in shuttling proteins and other mater...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030696 | Pride
Opn Cd44 Exosomes Β-catenin Renal fibrosis 
TranscriptomicsMultinucleated Tartrate Resistant Acid Phosphatase Positive Cells with Macrophage and Osteoclast Phenotypes in Bone
Prothrombin (PT) and osteopontin (OPN) promotes adhesion of different TRAP-positive multinucleated cells isolated from rat long bone (Hu et al. Exp Cell Res. 2008; 314: 638-50). The PT-adhering cell could represent either an immature precursor to the OPN-adherent osteoclast or constitute a distinct...
ORGANISM(S): Rattus norvegicus 
2010-12-31 | E-GEOD-19950 | biostudies-arrayexpress
GenomicsGene expression profile of B cells from OPN-competent and deficient Faslpr autoimmune mice
Gene expression profile of B cells from OPN-competent and deficient Faslpr autoimmune mice
PRJNA798003 | ENA
ProteomicsOsteopontin Regulation of MerTK+ Macrophages Promotes Crohn’s Disease Intestinal Fibrosis
The pathogenesis of intestinal fibrosis in Crohn’s disease (CD) remains unclear. Mer receptor tyrosine kinase (MerTK) is an immunosuppressive protein specifically expressed in macrophages. Osteopontin (OPN), also known as secreted phosphoprotein 1, contributes to inflammation and wound repair. This ...
ORGANISM(S): Mus Musculus 
PXD052743 |
TranscriptomicsIdentification of therapeutic targets for glioblastoma by network analysis
In this study, we confirmed that transformed dedifferentiated astrocytes and neurons acquired a stem/progenitor cell state, although they still retained gene expression memory from their parental cell-type. Transcriptional network analysis on transformed cells revealed up-regulation of genes involve...
ORGANISM(S): Mus musculus 
2015-05-11 | E-GEOD-64411 | biostudies-arrayexpress
UnknownOPN gene polymorphisms influence the risk of knee OA and OPN levels in synovial fluid in a Chinese population.
Not available
S-EPMC3672660 | biostudies-literature
UnknownCurcumin Veto the Effects of Osteopontin (OPN) Specific Inhibitor on Leukemic Stem Cell Colony Forming Potential via Promotion of OPN Overexpression.
Not available
S-EPMC4969556 | biostudies-literature
TranscriptomicsGene expression profile of B cells from OPN-competent and deficient Faslpr autoimmune mice
We performed gene expression profile on splenic CD19+ cells from autoimmune Faslpr/lpr and OPN-/-Faslpr/lpr mice to investigate the dynamics at the basis of the more incident transformation characterizing OPN-deficient animals. GEP on splenic CD19+ from BALB/c and OPN-/- mice was performed as contro...
ORGANISM(S): Mus musculus 
2022-12-21 | GSE193790 | GEO
UnknownBiological and Clinicopathological Characteristics of OPN in Cervical Cancers.
Not available
S-EPMC9163571 | biostudies-literature
GenomicsRab37-mediated OPN secretion enriches SPP1+ macrophages through autocrine–paracrine signaling to drive lung tumor progression
Rab37-mediated OPN secretion enriches SPP1+ macrophages through autocrine–paracrine signaling to drive lung tumor progression
PRJNA1368629 | ENA
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