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TranscriptomicsExpression data from mouse optic nerve head after optic nerve crush
Reactive gliosis is a complex process that involves profound changes in gene expression. We used microarray to indentify differentially expressed genes and to investigate the molecular mechanisms of reactive gliosis in optic nerve head in response to optic nerve crush injury. C57Bl/6 female mice wer...
ORGANISM(S): Mus musculus 
2013-07-15 | E-GEOD-40857 | biostudies-arrayexpress
MetabolomicsLipidomics of inflammation-induced optic nerve regeneration
Not available
ORGANISM(S): Rattus norvegicus 
ST000963 | MetabolomicsWorkbench
TranscriptomicsExpression data from mouse optic nerve head after elevation in intraocular pressure
Reactive astrocytes are typically studied in models that cause irreversible mechanical damage to axons, neuronal cell bodies, and glia. We evaluated the response of astrocytes in the optic nerve head to a subtle injury induced by a brief, mild elevation of the intraocular pressure. Astrocytes demo...
ORGANISM(S): Mus musculus 
2013-05-17 | E-GEOD-40009 | biostudies-arrayexpress
ProteomicsThe proteome of human retrobulbar optic nerve
The optic nerve is a white matter tract that conveys visual information to the brain. A detailed investigation of the proteome of the normal human retrobulbar optic nerve may help facilitate studies of the biology and pathophysiology of the optic nerve. We conducted an in-depth proteomic analysis of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-13 | MSV000081934 | MassIVE
TranscriptomicsDifferential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush
Retinal ganglion cell (RGC) death is the final consequence of many blinding diseases, where there is considerable variation in the time course and severity of RGC loss. Indeed, this process appears to be influenced by a wide variety of genetic and environmental factors. In this study we explored the...
ORGANISM(S): Mus musculus 
2010-08-19 | E-GEOD-17117 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of rat retina after intra-orbital nerve transection, intra-orbital nerve crush or no treatment
Array experiment: Animals were divided into a control group (naive), which did not undergo any experimental manipulation (n=20) and two experimental groups, one receiving an intra-orbital nerve transection (IONT, n=60) and the other an intra-orbital nerve crush (IONC, n=60) Sterile precautions were ...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-MEXP-1387 | biostudies-arrayexpress
MetabolomicsLipid profile Dataset of optogenetics induced optic nerve regeneration
Not available
ORGANISM(S): Mus musculus 
ST001381 | MetabolomicsWorkbench
ProteomicsThe proteome of human retrobulbar optic nerve
The optic nerve is a white matter tract that conveys visual information to the brain. A detailed investigation of the proteome of the normal human retrobulbar optic nerve may help facilitate studies of the biology and pathophysiology of the optic nerve. We conducted an in-depth proteomic analysis of...
ORGANISM(S): Homo sapiens (Human) 
2016-08-24 | PXD001581 | Pride
Eye / human / optic nerve / proteome 
TranscriptomicsDifferential gene expression in Danio rerio during optic nerve regeneration
To gain a better understanding of the factors necessary for successful CNS regeneration, a temporal analysis of the changes in gene expression in the eye caused by optic nerve injury was conducted. Dual color oligonucleotide microarrays were used to compare total RNA harvested from the eyes of sham...
ORGANISM(S): Danio rerio 
2010-05-16 | E-GEOD-17854 | biostudies-arrayexpress
MetabolomicsHuman Optic Nerve Glaucoma and Control Lipidomes
Not available
ORGANISM(S): Homo sapiens 
ST001442 | MetabolomicsWorkbench
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