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ProteomicsORF1p partners in dopaminergic neurons
We and others have previously observed a widespread expression of ORF1p in mouse and human neurons at steady-state. This somewhat surprising presence of ORF1p in neurons evokes the question of a possible physiological role of ORF1p specific to these cells. To address this question, we used a quantit...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-07-23 | PXD066047 | Pride
Line-1 Dopaminergic neurons Orf1p 
ProteomicsReverse Transcriptase Inhibitors regulate LINE-1 expresion, modulate ORF1p protein interactions, and activate autophagy in cancer cells
Long Interspersed Element-1 (LINE-1; L1) is an autonomous retrotransposon whose expression is frequently dysregulated in cancer. L1 encodes two proteins, ORF1p and ORF2p, which are essential for retrotransposition. Reverse transcriptase inhibitors (RTIs), including nucleoside (NRTIs) and non-nucleos...
ORGANISM(S): Homo sapiens (Human) 
2026-08-17 | PXD082586 | Pride
Human  ip-ms  line-1  orf1p 
ProteomicsORF1p interactors in the mouse brain
Mass spectrometry analysis of endogenous LINE-1 encoded ORF1p interactors in the mouse brain.
ORGANISM(S): Mus musculus (Mouse) 
2024-09-10 | PXD047160 | Pride
Orf1p transposable elements line-1 brain 
TranscriptomicsATAC-seq with and without siRNA ORF1 in post-mitotic human dopaminergic neurons (LUHMES cell line, differentiated)
LINE-1 are the only active and autonomous transposable elements in the human genome and encode two proteins, the nucleic acid chaperone ORF1p and ORF2p, which has reverse transcriptase and endonuclease activities. ORF1p is present at steady-state in human and mouse neurons in the adult brain, but a ...
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-15871 | biostudies-arrayexpress
TranscriptomicsRNA-seq with and without siRNA ORF1 in post-mitotic human dopaminergic neurons (LUHMES cell line, differentiated)
LINE-1 are the only active and autonomous transposable elements in the human genome and encode two proteins, the nucleic acid chaperone ORF1p and ORF2p, which has reverse transcriptase and endonuclease activities. ORF1p is present at steady-state in human and mouse neurons in the adult brain, but a ...
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-15856 | biostudies-arrayexpress
ProteomicsCharacterization of L1 ORF1p macromolecular complexes from Mael-/- mouse testes
piRNA-deficient Maelstrom (Mael) null mice are characterized by a strong upregulation of retrotransposon LINE-1 (L1) in meiotic spermatocytes. This defect turns out in the accumulation of L1 RNA and ORF1p in their cytoplasm and the formation of prominent ribonucleoprotein aggregates. We used 3-month...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-26 | PXD039425 | Pride
Mouse Retrotransposon line-1 Ribonucleoprotein Germ cell Meiosis 
GenomicsLINE-1 ORF1p immune evasion mechanisms in pancreatic ductal adenocarcinoma
LINE-1 ORF1p immune evasion mechanisms in pancreatic ductal adenocarcinoma
PRJNA1211127 | ENA
GenomicsLINE-1 ORF1p is a Shared and Immunogenic Antigen in Cancer
LINE-1 ORF1p is a Shared and Immunogenic Antigen in Cancer
PRJNA1305349 | ENA
GenomicsProfiling of RNAs associated with LINE-1 ORF1p in pancreatic ductal adenocarcinoma
Profiling of RNAs associated with LINE-1 ORF1p in pancreatic ductal adenocarcinoma
PRJNA1211128 | ENA
ProteomicsHuman LINE-1 ORF1p complex LC-MS/MS
Host proteins regulate LINE-1 (L1) retrotransposition. Here, we use immunoprecipitation followed by liquid chromatography-tandem mass spectrometry to identify proteins that associate with the L1 ORF1-encoded protein (ORF1p) in ribonucleoprotein particles.
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038851 | Pride
Human Retrotransposon Line-1 
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