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ProteomicsSARS-CoV-2 ORF8 interactome in the secretory pathway
The replication machinery of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely associated with the endoplasmic reticulum (ER) in host cells. Activation of the unfolded protein response (UPR) is a strategy hijacked by coronavirus to facilitate its replication and suppress ho...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD032035 | Pride
Orf8 2-d gel Endoplasmic reticulum Lc-ms/ms 
ProteomicsSecreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets the respiratory epithelium, yet severe disease features diffuse lung injury and hyperinflammatory syndromes driven by dysregulated immune activation. Emerging evidence indicates that resident and infiltrating immune cells...
ORGANISM(S): Homo sapiens (Human) 
2026-08-07 | PXD069220 | Pride
Sars-cov-2  orf8  macrophage  ace2  pyroptosis  il-1β  brodalumab 
ProteomicsSARS-CoV-2 protein encoded by ORF8 contains a histone mimic, disrupts chromatin regulation, and enhances replication
SARS-CoV-2 emerged in China at the end of 2019 and caused the global pandemic of COVID-19, a disease with high morbidity and mortality. While our understanding of this new virus is rapidly increasing, gaps remain in our understanding of how SARS-CoV-2 can effectively suppress host cell antiviral res...
ORGANISM(S): Homo sapiens (Human) 
2022-07-22 | PXD034379 | Pride
Epigenetics Infectious disease Sars-cov-2 
GenomicsRNAseq analysis of HEK293T expressing GFP, Orf8, or Orf8 with an ARKSAP deletion
RNAseq analysis of HEK293T expressing GFP, Orf8, or Orf8 with an ARKSAP deletion
PRJNA774812 | ENA
GenomicsChIP sequencing following infection with CoV-02 Orf8 KO
ChIP sequencing following infection with CoV-02 Orf8 KO
PRJNA775005 | ENA
GenomicsViral mimicry of Interleukin-17A by SARS-COV-2 ORF8
Viral mimicry of Interleukin-17A by SARS-COV-2 ORF8
PRJNA804953 | ENA
GenomicsATACseq analysis of HEK cells transfected with SARS-CoV-2 protein Orf8
ATACseq analysis of HEK cells transfected with SARS-CoV-2 protein Orf8
PRJNA774814 | ENA
TranscriptomicsRNAseq analysis of HEK293T expressing GFP, Orf8, or Orf8 with an ARKSAP deletion
Analysis of histone mimicry by SARS-CoV-2 Orf8 encoded protein
ORGANISM(S): Homo sapiens 
2022-07-20 | GSE186625 | GEO
GenomicsChIP sequencing following infection with CoV-02 Orf8 or ARKSAP KO
ChIP sequencing following infection with CoV-02 Orf8 or ARKSAP KO
PRJNA844885 | ENA
GenomicsChIP-seq analysis of HEK cells transfected with SARS-CoV-2 protein Orf8
ChIP-seq analysis of HEK cells transfected with SARS-CoV-2 protein Orf8
PRJNA687038 | ENA
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