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Lysosome-Related Organelles Orchestrate Biogenic Crystal Formation in Pigment Cells
Selective RNA modification in situ by circular gRNAs in designer organelles
Organelles from Pichia, either grown on glucose or methanol were purified and analysed using LC-ESI-MS. Two biological replicates each had been analyzed leading to four replicate data sets for every organelle. Organelles analyzed: cis golgi, trans golgi, plasma membrane, microsomes, cytosol, vacuole...
ORGANISM(S): Komagataella pastoris (Yeast) (Pichia pastoris) 
2020-05-26 | PXD011220 | Pride
Iron accumulation and changes of cellular organelles in WDR45 mutant fibroblasts
Lysosome-related organelles (LROs) enable cell-type-specific functions by adapting endolysosomal pathways for specialized roles. Here, we show that iridosomes - optically active, guanine crystal-forming organelles in zebrafish iridophores - constitute a previously unrecognized class of LROs. Using t...
ORGANISM(S): Danio rerio 
2026-03-19 | GSE297759 | GEO
Precision RNA Base Editing in Plant Organelles Using Engineered Synthetic P-type PPR Editing Factors
Here, we have utilized a sub-cellular proteomics approach to analyze the localization of proteins in the nucleus, mitochondria, crude membrane, cytoplasm, heavy and light microsomes. Out of 2002 reproducibly identified proteins, we detected 762 proteins in a single organelle whereas 160 proteins wer...
ORGANISM(S): Homo sapiens (Human) 
2017-04-26 | PXD006271 | Pride
Iron overload in the brain, defined as excess stores of iron, is known to be related to neurological disorder. Among neurodegeneration with brain iron accumulation, we reported a specific point mutation, 977-1G>A in WDR45, showing iron accumulation in the brain, and autophagy defects in the fibrobla...
ORGANISM(S): Homo sapiens 
2021-11-17 | GSE184520 | GEO
The protozoan Giardia lamblia is a unique biological model to investigate minimal cellular mechanisms because it is an early‐diverged eukaryote that has undergone reductive evolution and has minimized or lost organelles such as mitochondria, peroxisomes, the endo-lysosomal system and a Golgi apparat...
ORGANISM(S): Giardia lamblia ATCC 50803 
2014-03-11 | PXD000694 | Pride
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