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MetabolomicsOrganotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations
BACKGROUND: Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic in...
2019-02-08 | MTBLS669 | MetaboLights
TranscriptomicsA comparison of mono-culture and co-culture model containing fibroblasts
Organotypic three dimensional cultures of epithelial cells are grown at the air–liquid interface (ALI) and resemble the in vivo counterparts. Although the complexity of in vivo cellular responses could be better manifested in co-culture models in which additional cell-types such as fibroblasts were ...
ORGANISM(S): Homo sapiens 
2015-06-12 | E-MTAB-3462 | biostudies-arrayexpress
TranscriptomicsA novel 3-D organotypic culture model by co-culturing alpha-SMA positive CAF and cholangiocarcinoma cells in a collagen matrix
The increased M-NM-1-smooth muscle-actin positive cancer-associated fibroblastic cells (CAF) in the desmoplastic stroma may relate to a more aggressive cancer and worse survival outcomes for intrahepatic cholangiocarcinoma (ICC) patients We developed a novel 3-D organotypic culture model by co-cultu...
ORGANISM(S): Rattus norvegicus 
2012-06-22 | E-GEOD-38889 | biostudies-arrayexpress
ProteomicsAn organotypic model of human skin simulates the dermonecrotic effects of Naja nigricollis envenoming
Snakebite envenoming is a neglected tropical disease that kills and maims hundreds of thousands annually. Naja nigricollis, the black-necked spitting cobra, has a cytotoxin-rich venom that is able to cause severe dermonecrosis and is not efficiently neutralized by current antivenoms. Here, we introd...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-01-11 | PXD033111 | Pride
Dermonecrosis Snakebite envenoming Naja nigricollis Skin organotypic Proteomics Cytotoxin Keratinocyte 3d cell culture Dda Lc-ms/ms 
Genomics3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis
3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis
PRJNA774268 | ENA
ProteomicsTranscriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticity
Understanding the mechanisms of synaptic plasticity is crucial for elucidating how the brain adapts to internal and external stimuli. A key objective of plasticity is maintaining physiological activity states during perturbations by adjusting synaptic transmission through negative feedback mechanism...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD056794 | Pride
Transcriptome Proteomics Organotypic tissue culture Homeostatic synaptic plasticity 
TranscriptomicsComparison of gene expression profiles of normal human bronchial epithelial cells in 2D and 3D cultural conditions
The experiment is part of a project to study DNA repair process after ionizing radiation in organotypic 3-dimentional human bronchial epithlial cell culture. Human bronchial epithelial cells were grown in tissue culture flask (2D) or in matrics gel (3D). Three independent cultures were done for eac...
ORGANISM(S): Homo sapiens 
2011-07-26 | E-GEOD-27520 | biostudies-arrayexpress
TranscriptomicsIN VITRO ASSESSMENT OF ACUTE EXPOSURE OF THS2.2 AEROSOL ON ORGANOTYPIC ACUTE HUMAN NASAL TISSUE CULTURES
In vitro toxicology approaches have evolved, from a focus on the molecular changes within a cell to understanding of toxicity-related mechanisms that simulate the in vivo environment. The recent development of three dimensional (3-D) organotypic nasal epithelial culture models offer a physiologicall...
ORGANISM(S): Homo sapiens 
2016-08-31 | E-MTAB-4740 | biostudies-arrayexpress
TranscriptomicsIN VITRO ASSESSMENT OF ACUTE EXPOSURE OF THS2.2 AEROSOL ON ORGANOTYPIC ACUTE HUMAN ORAL TISSUE CULTURES
Besides its well-known effects increasing predisposition to oral cancer, cigarette smoke (CS) exposure is an important risk factor for many conditions including periodontal diseases, gingivitis and other benign mucosal disorders. Smoking cessation remains the most effective approach for minimizing r...
ORGANISM(S): Homo sapiens 
2016-07-26 | E-MTAB-4742 | biostudies-arrayexpress
UnknownImaging pathological activities of human brain tissue in organotypic culture.
Not available
S-EPMC5983351 | biostudies-literature
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