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MetabolomicsMetabolic effects of an aspartate aminotransferase-inhibitor on two T-cell lines
An emerging method to help elucidate the mode of action of experimental drugs is to use untargeted metabolomics of cell-systems. The interpretations of such screens are however complex and more examples with inhibitors of known targets are needed. Here two T-cell lines were treated with an inhibitor...
2018-12-04 | MTBLS789 | MetaboLights
GenomicsOrnithine aminotransferase supports polyamine synthesis in pancreatic cancer
Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer
PRJNA796043 | ENA
ProteomicsProteomic characterization of infant and adult ornithine aminotransferase-deficient mice
The deficiency of ornithine aminotransferase (OAT) cause gyrate atrophy, a progressive chorioretinal degeneration disease culminating in blindness. This project investigates age- and tissue-specific proteomic changes in the retina, retinal pigment epithelium (RPE), and liver of OAT-deficient mice to...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-06 | PXD063614 | Pride
Ornithine Metabolism Ornithine aminotransferase Proteomics Gyrate atrophy Retina pigment epithelium Liver Oat Retina 
TranscriptomicsOrnithine aminotransferase supports polyamine synthesis in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) cells have a distinct dependence on de novo ornithine synthesis from glutamine via ornithine aminotransferase (OAT), which supports polyamine synthesis and is required for tumor growth. This directional OAT activity is normally largely restricted to infancy and...
ORGANISM(S): Homo sapiens 
2023-01-01 | GSE193411 | GEO
TranscriptomicsTranscription profiling of human leukocytes to measure the postprandial effect of an oat bran meal on heathy subjects
The goal was to measure the postprandial effect of an oat bran meal on gene expression in leukocytes from healthy subjects and to investigate the postprandial glucose, insulin and triglyceride responses. Linear mixed models were used for the array data to study the simultaneous dependency on many fa...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-MEXP-2261 | biostudies-arrayexpress
UnknownOrnithine aminotransferase supports polyamine synthesis in pancreatic cancer.
Not available
S-EPMC10929664 | biostudies-literature
UnknownLiver-directed gene therapy for ornithine aminotransferase deficiency.
Not available
S-EPMC10086579 | biostudies-literature
UnknownLiver-directed gene therapy for ornithine aminotransferase deficiency.
Not available
S-SCDT-10_15252-EMMM_202217033 | biostudies-other
UnknownSuppression of Hepatocellular Carcinoma by Inhibition of Overexpressed Ornithine Aminotransferase.
Not available
S-EPMC4538432 | biostudies-literature
UnknownA neonate with ornithine aminotransferase deficiency; insights on the hyperammonemia-associated biochemical phenotype of gyrate atrophy.
Not available
S-EPMC9248225 | biostudies-literature
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