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MetabolomicsOrnithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis of Helicobacter pylori Infection

Colonization by H. pylori is associated with a wide range of gastric diseases, ranging from superficial gastritis to more severe pathologies, including intestinal metaplasia and adenocarcinoma. The interplay of the host response and the pathogen affect the outcome of disease. One major component ...

2022-06-15 | MTBLS3235 | MetaboLights
MetabolomicsAcupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine
Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending MM patient survival. However, most patients a...
2022-02-21 | MTBLS3487 | MetaboLights
ProteomicsEPLIN-Beta is a novel substrate of ornithine decarboxylase antizyme 1, mediating cellular migration
Polyamines promote cellular proliferation, and their levels are controlled by ornithine decarboxylase antizyme 1 (Az1), through the proteasome-mediated, ubiquitin-independent degradation of ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis. Az1-mediated degradation of...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD039865 | Pride
Ubiquitin-independent degradation Antizyme Cell migration Eplin/lima1 
TranscriptomicsOrnithine decarboxylase is sufficient for prostate tumorigenesis via androgen receptor signaling
Ornithine decarboxylase is sufficient for prostate tumorigenesis via androgen receptor signaling
ORGANISM(S): Homo sapiens 
2016-06-03 | GSE82179 | GEO
ProteomicsProfiling proteome changes during polyamine depletion within the Leishmania donovani polyamine pathway gene deletion mutants, del-odc (ornithine decarboxylase) and del-spdsyn (spermidine synthase)
Polyamines are aliphatic polycations that have emerged as important determinants of cell growth and viability in rapidly proliferating cells, including in the pathogenic protozoan parasite Leishmania donovani. In L. donovani, the polyamine spermidine is synthesized by the successive conversion of or...
ORGANISM(S): Leishmania donovani BPK282A1 
2022-08-29 | PXD036349 | Pride
Psr-ohsu Leishmania Starvation Ornithine decarboxylase Stress-response Spermidine synthase Quantitative proteomics Polyamine Tandem mass tags 
UnknownTargeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression.
Not available
S-EPMC5859467 | biostudies-literature
UnknownInhibition of ornithine decarboxylase restores hypoxic pulmonary vasoconstriction in endotoxemic mice.
Not available
S-EPMC7745575 | biostudies-literature
UnknownOrnithine decarboxylase antizyme Oaz3 modulates protein phosphatase activity.
Not available
S-EPMC3156769 | biostudies-literature
GenomicsOrnithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription
Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription
PRJNA884137 | ENA
UnknownOrnithine Decarboxylase Activity Is Required for Prostatic Budding in the Developing Mouse Prostate.
Not available
S-EPMC4591331 | biostudies-literature
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