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MetabolomicsSystem Xc- exacerbates metabolic stress under glucose depletion in oral squamous cell carcinoma

OBJECTIVE: Emerging evidence suggests that glucose depletion (GD)-induced cell death depends on system Xc-, a glutamate/cystine antiporter extensively studied in ferroptosis. However, the underlying mechanism remains debated. Our study confirmed the correlation between system Xc...

2024-01-16 | MTBLS5358 | MetaboLights
MetabolomicsMechanistic study of the effects of salivary components from OSCC patients on tumor growth using a mouse model of oral squamous cell carcinoma

Mechanistic study of the effects of salivary components from OSCC patients on tumor growth using a mouse model of oral squamous cell carcinoma

2025-08-01 | MTBLS12805 | MetaboLights
ProteomicsA proteomic signature for human papillomavirus-associated oropharyngeal squamous cell carcinoma predicts patients at high risk of recurrence
The incidence of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is increasing and effective treatment for targeting the subset of patients at high risk for recurrence remains a significant clinical challenge. In this study, pre-treatment tumour biopsies were used...
ORGANISM(S): Homo sapiens (Human) 
2025-02-23 | PXD036891 | Pride
Hpv Human papillomavirus Data-independent acquisition Dia Predictive biomarkers Opscc Oropharyngeal squamous cell carcinoma Proteomics 
ProteomicsDevelopment of a potential salivary biomarker panel for Oral Squamous Cell Carcinoma using a proteomics-based approach.
Oral Squamous Cell Carcinoma (OSCC) is one of the most prevalent cancers in the world with the maximum number of cases reported from India. Poor survival rate associated with OSCC can be attributed to the non-availability of a biomarker, as one of the major reasons, leading to late presentation. Ide...
ORGANISM(S): Homo Sapiens 
2021-07-09 | PXD020263 | panorama
ProteomicsiTRAQ-based quantitative proteomics analysis of human HNSCC cells
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer and is major cause of cancer mortality and morbidity. It emerges within oral cavity, lip, tongue, floor of the mouth, nasopharynx, palate, gingival and larynx, is common cancer worldwide especially in Southeast Asia and So...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-14 | MSV000079580 | MassIVE
TranscriptomicsmiR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis.
For the purpose of analyzing mechanisms related to the cis-diamminedichloroplatinum (CDDP) resistance in head and neck squamous cell carcinoma (head and neck SCC), we employed a nasal squamous cell carcinoma (nasal SCC) cell line RPMI2650 and its CDDP resistant substrain RPMI2650CR previously descri...
ORGANISM(S): Homo sapiens 
2012-06-13 | E-GEOD-32176 | biostudies-arrayexpress
ProteomicsThe HLA-ligandome of oropharyngeal squamous cell carcinomas reveals shared tumor-exclusive peptides for semi-personalized vaccination
Oropharyngeal squamous cell carcinoma (OPSCC) is diagnosed in 93,000 patients worldwide per year and 51,000 annual deaths can be attributed to this disease. OPSCCs are either human papillomavirus associated (HPV-positive) cancers or non-virally induced, primarily tobacco and alcohol associated (HPV-...
ORGANISM(S): Homo sapiens (Human) 
2023-02-27 | PXD033383 | Pride
Hpv Hla Tumor-associated antigen Oropharyngeal squamous cell carcinoma Mass spectrometry Opscc Immunopeptidome Immunopeptidomics 
GenomicsTranscriptomic Profiling of Oropharyngeal Squamous Cell Carcinoma
Transcriptomic Profiling of Oropharyngeal Squamous Cell Carcinoma
PRJNA842485 | ENA
GenomicsTranscriptomic Profiling of Oropharyngeal Squamous Cell Carcinoma
Transcriptomic Profiling of Oropharyngeal Squamous Cell Carcinoma
PRJNA842484 | ENA
TranscriptomicsMethylationEPIC array from fresh oral and oropharyngeal tissue samples from head and neck squamous cell carcinoma patients, tissue samples from potentially premalignant oral lesions and fresh tonsil tissue samples from control patients
This data was used to detect good biomarkers for head and neck squamous cell carcinoma and was integrated with transcriptome and miRNome data aiming to elucidate role of epigenetics on gene expression in head and neck squamous cell carcinoma.
ORGANISM(S): Homo sapiens 
2024-04-22 | E-MTAB-13954 | biostudies-arrayexpress
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