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MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
ProteomicsQuantitative proteomics of immunocaptured mitochondria from Purkinje Cells
Mitochondria vary in morphology and function in different tissues, however little is known about their molecular diversity among cell types. To investigate mitochondrial diversity in vivo, we developed an efficient protocol to isolate cell type-specific mitochondria based on a new MitoTag mouse. We ...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-03 | PXD010772 | Pride
Mitochondria Purkinje cells Neurons 
ProteomicsQuantitative proteomics of immunocaptured mitochondria from Astrocytes
Mitochondria vary in morphology and function in different tissues, however little is known about their molecular diversity among cell types. To investigate mitochondrial diversity in vivo, we developed an efficient protocol to isolate cell type-specific mitochondria based on a new MitoTag mouse. We ...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-03 | PXD010781 | Pride
Astrocytes Mitochondria 
ProteomicsQuantitative proteomics of immunocaptured mitochondria from Granule cells
Mitochondria vary in morphology and function in different tissues, however little is known about their molecular diversity among cell types. To investigate mitochondrial diversity in vivo, we developed an efficient protocol to isolate cell type-specific mitochondria based on a new MitoTag mouse. We ...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-03 | PXD010774 | Pride
Mitochondria Granule cells Neurons 
ProteomicsCerebellum Proteomics - Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity
A whole cerebellum proteome analysis was performed to compare the data to cell specific mitochondria proteomics in the same brain region.
ORGANISM(S): Mus musculus (Mouse) 
2019-09-03 | PXD013380 | Pride
Cerebellum Brain Mouse 
UnknownModulation of GPR133 (ADGRD1) signaling by its intracellular interaction partner extended synaptotagmin 1.
Not available
S-EPMC11209873 | biostudies-literature
UnknownThe expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability.
Not available
S-EPMC10841603 | biostudies-literature
UnknownBaseline predictors for one-year visual outcomes with ranibizumab or bevacizumab for neovascular age-related macular degeneration.
Not available
S-EPMC3536921 | biostudies-literature
UnknownSARS-CoV-2 RNA and Nucleocapsid Antigen Are Blood Biomarkers Associated With Severe Disease Outcomes That Improve in Response to Remdesivir.
Not available
S-EPMC11420797 | biostudies-literature
UnknownMacular morphology and visual acuity in the comparison of age-related macular degeneration treatments trials.
Not available
S-EPMC3737287 | biostudies-literature
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