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ProteomicsComplexome profiling of mitochondria to study organismic consequences of aging in Podospora anserina
Podospora anserina is an established aging model with a strong mitochondrial etiology of aging. Here we performed a complexome analysis of isolated mitochondria to study age-related changes of assembled mitochondrial protein complexes. The analysis revealed prominent age-related alterations in oxida...
ORGANISM(S): Podospora anserina 
2022-02-22 | PXD029352 | Pride
Lc-msms Podospora anserina Oxidative phosphorylation system Mitochondria Aging Complexome profiling 
TranscriptomicsA genome-wide longitudinal transcriptome analysis of the aging model Podospora anserina
Aging of biological systems is controlled by various processes which have a potential impact on gene expression. Here we report a genome-wide transcriptome analysis of the fungal aging model Podospora anserina. Total RNA of three individuals of defined age were pooled and analyzed by SuperSAGE (seri...
ORGANISM(S): Podospora anserina 
2013-12-20 | E-MTAB-2016 | biostudies-arrayexpress
UnknownSimultaneous Ablation of the Catalytic AMPK α-Subunit SNF1 and Mitochondrial Matrix Protease CLPP Results in Pronounced Lifespan Extension.
Not available
S-EPMC7969656 | biostudies-literature
UnknownCLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation.
Not available
S-EPMC10886707 | biostudies-literature
ProteomicsProteome of WT and CLPP-null Podospora Anserina
Mutations in the gene for the mitochondrial matrix protease CLPP can cause human Perrault syndrome, which is characterized by male and female infertility, progressive sensorineural deafness, ataxia and leukoencephalopathy. This gene encodes a peptidase that is conserved since bacteria and localizes ...
ORGANISM(S): Podospora anserina 
2024-06-22 | PXD048640 | Pride
Clpp Posospora anserina Perrault syndrome 
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