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MetabolomicsOverexpression of the vascular brassinosteroid receptor BRL3 confers drought resistance without penalizing plant growth

Drought represents a major threat to food security. Mechanistic data describing plant responses to drought have been studied extensively and genes conferring drought resistance have been introduced into crop plants. However, plants with enhanced drought resistance usually display lower growth, hi...

2021-05-17 | MTBLS2289 | MetaboLights
TranscriptomicsCentral role of FaGAMYB in the transition of the strawberry receptacle from development to ripening
The study assigns a key regulatory role of FaGAMYB in the initiation of strawberry receptacle ripening and acting upstream of the known regulator ABA. Down-regulation of FaGAMYB caused an arrest in the ripening of receptacle and inhibited colour formation. Consistent with this, several transcription...
ORGANISM(S): Fragaria x ananassa 
2015-04-14 | E-MTAB-3496 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of BRCA1-mutated breast tumors
Background: Breast cancer is a complex disease, encompassed by different clinically and molecularly stratified entities. In 2000, Perou and colleagues demonstrated that tumor phenotypic diversity correlates with differences in global gene expression patterns, which in turn reflect aspects of the bio...
ORGANISM(S): Homo sapiens 
2009-10-14 | E-GEOD-12350 | biostudies-arrayexpress
MetabolomicsDeep insights into microsampling technologies for global lipidomic profiling of human whole blood using high-throughput LC-MS

In recent years, blood microsampling (BμS) technologies have gained popularity, as they offer simplicity, minimal invasiveness, and suitability for remote sample collection. In this study, the aim was to explore the potential of three BμS devices for reliable untargeted lipidomic profiling using ...

2025-09-30 | MTBLS10722 | MetaboLights
TranscriptomicsExpression data from pig uterus in response to embryos at blastocyst satge and oocytes
The maternal tract plays a critical role in the success of early embryonic development providing an optimal environment for establishment and maintenance of pregnancy. Preparation of this environment requires an intimate dialogue between the embryo and her mother. To advance our understanding of the...
ORGANISM(S): Sus scrofa 
2012-04-18 | E-GEOD-33262 | biostudies-arrayexpress
ProteomicsSyndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival
Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic options. Here, we show that syndecan-4 (SDC4), a plasma membrane proteoglycan, is highly expressed in intestinal subtype gastric tumours and that this signature associates with patients’ poor survival. Furth...
ORGANISM(S): Homo sapiens (Human) 
2023-05-05 | PXD035679 | Pride
Extracellular vesicles Extracellular communication Gastric cancer Syndecan-4 Heparan sulfate proteoglycans Cancer cell invasion 
MetabolomicsIntegrating Blood Microsampling Devices with CE-MS for Untargeted Analysis of Polar Metabolomics

Capillary electrophoresis–mass spectrometry (CE-MS) offers considerable advantages for polar compound metabolomics analysis, including simple workflows, fast method development, and suitability for small sample volumes. Blood microsampling (BμS) techniques (such as dried blood spots, quantitative...

2026-01-13 | MTBLS13090 | MetaboLights
UnknownGermline missense pathogenic variants in the BRCA1 BRCT domain, p.Gly1706Glu and p.Ala1708Glu, increase cellular sensitivity to PARP inhibitor olaparib by a dominant negative effect.
Not available
S-EPMC5815624 | biostudies-literature
TranscriptomicsmiRNA expression in healthy carriers of heterozygous BRCA1 mutation and healthy WT controls
In order to investigate whether carriers of BRCA1 heterozygous mutation show altered miRNA expression profiles, we established a panel of lymphoblastoid cell lines (LCLs) harboring either mutated or WT BRCA1 (control) and investigated their miRNA expression profiles. We were especially interested wh...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-60444 | biostudies-arrayexpress
UnknownmiRNA expression profiling in hereditary breast tumors
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-44899 | biostudies-other
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