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MetabolomicsMetabolomic analysis of synovial fluid from Thoroughbred racehorses diagnosed with palmar osteochondral disease using magnetic resonance imaging

BACKGROUND: Palmar osteochondral disease (POD) is a common cause of lameness in competition horses. Magnetic resonance imaging (MRI) is the most sensitive diagnostic modality currently available, however it may not be financially or logistically practical for routine screening o...

2021-11-12 | MTBLS1435 | MetaboLights
ProteomicsTissue Catabolism and Donor-Specific Dexamethasone Response in a Human Osteochondral Model of Post-Traumatic Osteoarthritis
We present an ex vivo human osteochondral model of PTOA to investigate disease effects on catabolism and cellular homeostasis in a multi-tissue system and discover biomarkers for disease progression and drug efficacy.
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD032213 | Pride
Proteomics Ptoa model Osteochondral Explant culture Dexamethasone 
GenomicsSingle-cell RNA sequencing for osteochondral fusions
Single-cell RNA sequencing for osteochondral fusions
PRJNA1153927 | ENA
ProteomicsMultifunctional polyphenol-based silk hydrogel alleviates oxidative stress and enhances endogenous regeneration of osteochondral defects
The native microenvironment following osteochondral defect is not permissive for its endogenous regeneration. A variety of hydrogels have been developed to regulate cell behaviors; however, there is still a lack of hydrogels with multifunctional properties that can provide a supportive microenvironm...
ORGANISM(S): Rattus Rattus 
2021-11-28 | PXD030026 |
TranscriptomicsSingle-cell RNA sequencing for osteochondral fusions
We have developed a protocol to generate hPSC-derived osteochondral fusions that mimick embryonic long bone diaphysis. hPSCs were first differentiated to chondroprogenitors and osteogenesis-committed early chondrocytes. Then they were centrifuged together to genrate a fusion construct. After culture...
ORGANISM(S): Homo sapiens 
2025-02-21 | GSE275943 | GEO
GenomicsThe equine carpal osteochondral fragment model
The equine carpal osteochondral fragment model
PRJEB53619 | ENA
GenomicsGNAS/PKA pathway promotes aberrant osteochondral differentiation of Gli1+ tendon sheath progenitors
GNAS/PKA pathway promotes aberrant osteochondral differentiation of Gli1+ tendon sheath progenitors
PRJNA1271048 | ENA
UnknownOsteochondral Allograft Transplantation for Treatment of Focal Patellar Osteochondral Lesion.
Not available
S-EPMC5620468 | biostudies-literature
GenomicsSynchronised regeneration of osteochondral defects via spatially patterned implants of stable and hypertrophic cartilage organoids
Synchronised regeneration of osteochondral defects via spatially patterned implants of stable and hypertrophic cartilage organoids
PRJNA1289846 | ENA
TranscriptomicsGNAS/PKA pathway promotes aberrant osteochondral differentiation of Gli1+ tendon sheath progenitors
We have employed a single cell sequencing approach using 10x Genomics scRNAseq to study the identity and fate determination of Gli1+ tendon sheath progenitors in heterotopic ossification(HO) formation following tenotomy. Gli1 is a signature gene for several tissue-specific Mesenchymal stem cells (MS...
ORGANISM(S): Mus musculus 
2025-07-28 | GSE298748 | GEO
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