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ModelsGraham2013 - Role of osteocytes in targeted bone remodeling
Jason M. Graham, Bruce P. Ayati, Sarah A. Holstein & James A. Martin. The role of osteocytes in targeted bone remodeling: a mathematical model. PLoS ONE 8, 5 (2013). Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclas...
2024-09-02 | BIOMD0000000721 | BioModels
ProteomicsOsteocytes are not able to eliminate intracellular S. aureus and serves as a main reservoir for osteomyelitis
The main reservoir for Staphylococcus aureus osteomyelitis is the bone tissue where this pathogen can persist and form small colony variants for long periods within osteoblasts and osteocytes. Recently the osteocytes were described as a main reservoir for this pathogen in bone tissue. However, the m...
ORGANISM(S): Homo sapiens (Human) 
2022-08-02 | PXD029440 | Pride
Osteoblasts Osteocytes Staphylococcus aureus Osteomyelitis 
TranscriptomicsIn vitro and in vivo evidences of osteocytes involvement in myeloma-induced osteoclast formation and bone disease
The involvement of osteocytes in multiple myeloma (MM)-induced osteoclast formation and the occurrence of bone lesions are still unknown. Osteocytes regulate bone remodeling at least in part through the cell death and apoptosis triggering osteoclast recruitment and formation. In this study, firstly ...
ORGANISM(S): Homo sapiens 
2012-05-21 | E-GEOD-27372 | biostudies-arrayexpress
GenomicsSingle-cell RNA sequencing identifies Fgf23-expressing osteocytes
Single-cell RNA sequencing identifies Fgf23-expressing osteocytes
PRJNA911730 | ENA
GenomicsOsteocytes regulate skeletal senescence during development
Osteocytes regulate skeletal senescence during development
PRJNA835705 | ENA
GenomicsOsteocytes produce erythroferrone to regulate liver hepcidin during stress erythropoiesis
Osteocytes produce erythroferrone to regulate liver hepcidin during stress erythropoiesis
PRJNA1008726 | ENA
TranscriptomicsWhole gene expression data from osteocyte-like cell line MLO-Y4 under large gradient high magnetic field (LG-HMF)
osteocyte is the mechanosensor in bone, taking up pivotal position in mediating the mechano-induced bone remodeling. Dimagnetic levitation has been used to stimulating a reduced gravity environment for studing the effects of changed gravity to different organisms.we constructed a superconducting mag...
ORGANISM(S): Mus musculus 
2015-02-02 | E-GEOD-62128 | biostudies-arrayexpress
GenomicsPhysiological transcriptional profiling of murine osteocytes from calvaria and long bones
Physiological transcriptional profiling of murine osteocytes from calvaria and long bones
PRJNA818696 | ENA
MetabolomicsPrimary Osteocyte Supernatants Metabolomic Profiling of Two Transgenic Mice with Connexin43 Dominant Negative Mutants

Osteocytes could release some small molecules (≤ 1 kDa) through gap junctions and hemichannels to extracellular environment, such as prostaglandin E2 (PGE2), nitric oxide (NO) and adenosine triphosphate (ATP), which play key roles in transferring signals between bone cells and other tissue cells....

2021-04-14 | MTBLS2358 | MetaboLights
TranscriptomicsSingle-cell RNA sequencing identifies Fgf23-expressing osteocytes
Fibroblast growth factor 23 (FGF23), a hormone, mainly produced by osteocytes, regulates phosphate and vitamin D metabolism. By contrast, 1,25-dihydroxyvitamin D3, the active form of vitamin D, has been shown to enhance FGF23 production. While it is likely that osteocytes are heterogenous in terms o...
ORGANISM(S): Mus musculus 
2022-12-17 | GSE220836 | GEO
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