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TranscriptomicsRNA-seq of rat tissues with chronic osteomyelitis
We constructed a rat model of femoral osteomyelitis by injecting a mixture of Staphylococcus aureus suspension and LPS. Subsequently, we performed RNA-seq to compare the osteomyelitic femur with the normal femur group.
ORGANISM(S): Rattus norvegicus 
2025-12-10 | E-MTAB-16153 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of neutrophils from patients with chronic recurrent multifocal osteomyelitis (CRMO) and healthy age-matched controls
The goal is to identify differntially expressed genes in multifocal osteomyelitis (CRMO) neutrophils to understand the mechanism of neutrophil dysregulation contributing to CRMO development.
ORGANISM(S): Homo sapiens 
2026-09-18 | E-MTAB-16634 | biostudies-arrayexpress
ModelsLiò2012_Modelling osteomyelitis_Control Model
Background This work focuses on the computational modelling of osteomyelitis, a bone pathology caused by bacteria infection (mostly Staphylococcus aureus). The infection alters the RANK/RANKL/OPG signalling dynamics that regulates osteoblasts and osteoclasts behaviour in bone remodelling, i.e. the r...
2024-09-02 | BIOMD0000000923 | BioModels
ProteomicsOsteocytes are not able to eliminate intracellular S. aureus and serves as a main reservoir for osteomyelitis
The main reservoir for Staphylococcus aureus osteomyelitis is the bone tissue where this pathogen can persist and form small colony variants for long periods within osteoblasts and osteocytes. Recently the osteocytes were described as a main reservoir for this pathogen in bone tissue. However, the m...
ORGANISM(S): Homo sapiens (Human) 
2022-08-02 | PXD029440 | Pride
Osteoblasts Osteocytes Staphylococcus aureus Osteomyelitis 
Genomicsosteomyelitis
High-resolution transcriptomic analysis of the adaptive response of Staphylococcus aureus during acute and chronic phases of osteomyelitis infection
PRJEB6003 | ENA
GenomicsRNA-seq of rat tissues with chronic osteomyelitis
RNA-seq of rat tissues with chronic osteomyelitis
PRJEB102818 | ENA
GenomicsOsteomyelitis diabetic foot
Osteomyelitis diabetic foot Metagenome
PRJNA1270973 | ENA
TranscriptomicsCombination of single-cell and bulk RNA-seq reveals changes in the immune landscape in osteomyelitis
Objective: This study profiled the osteomyelitis immune micro-environment in depth, pinpointed driver genes and cell populations that fuel disease progression, and mined the data for actionable drug targets. Methods: We analyzed time-series transcriptomic sequencing data from mouse tibial osteomyeli...
ORGANISM(S): Mus musculus 
2026-02-25 | GSE311208 | GEO
TranscriptomicsApolipoprotein E deficiency potentiates macrophage resistance to staphylococcus aureus osteomyelitis via regulating cholesterol metabolism
To explore how APOE functions in the mechanism of regulation of cholesterol metabolism during S. aureus osteomyelitis, we established S. aureus osteomyelitis models in WT mice and APOE knockout mice. We then performed gene expression profiling analysis using data obtained from RNA-seq of bone marrow...
ORGANISM(S): Mus musculus 
2023-07-09 | GSE227521 | GEO
TranscriptomicsBiphasic effects of pleiotropic cytokine IL-27 during Staphylococcus aureus implant-associated osteomyelitis
We aimed to elucidate the mechanism of IL-27/ IL-27 receptor signaling effects on S. aureus osteomyelitis via gene expression studies.
ORGANISM(S): Mus musculus 
2021-03-16 | GSE168896 | GEO
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