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ProteomicsComparative analysis of proteomes and secretomes of human mesenchymal stem cells isolated from six sources during osteogenic differentiation
Ability to perform osteogenic differentiation is one of the minimal criteria of mesenchymal stem cells (MSCs). Still, it is generally unknown whether osteogenic differentiation is universal cell fate or various phenotypically similar cell states. Besides this, MSCs and their secretomes are actively ...
ORGANISM(S): Homo sapiens (Human) 
2023-11-05 | PXD037320 | Pride
Msc Timstof pro Osteogenic differeniation Secretome 
ProteomicsMolecular mechanisms of endothelial osteoinductive/osteosupressive properties
In vivo, osteogenesis is tightly connected with capillaries and endothelium assumed to be one of the main regulators of osteogenic differentiation of underling mesenchymal cell. In our experiments in vitro, we cultured human osteoblasts and human umbilical vein cord endothelial cells (HUVEC) in oste...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD037385 | Pride
Osteoblasts Timstof pro Osteogenic differeniation Endothelium Huvec 
GenomicsHistone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone 4 (H4) Epigenome (ChIP-Seq)
ChIP-Seq analysis revealed that suberoylanilidehydroxamic acid (SAHA) increases genome-wide H4 acetylation in differentially regulated genes, except for the 500 bp upstream of transcription start sites (TSS). Chromatin immunoprecipitation (ChIP) with massively parallel high throughput sequencing (Se...
ORGANISM(S): Mus musculus 
2013-09-04 | E-GEOD-50551 | biostudies-arrayexpress
TranscriptomicsHistone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone 4 (H4) Epigenome
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-09-04 | E-GEOD-50552 | biostudies-arrayexpress
TranscriptomicsHistone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone 4 (H4) Epigenome (BeadChip)
Suberoylanilidehydroxamic acid (SAHA) significantly increased the expression levels of 127 transcripts and suppressed expression of 130 genes by more than 2-fold within 3 standard deviations of the mean in differentiating MC3T3 sc4 osteoblasts Total RNA was obtained from differentiating MC3T3 sc4 c...
ORGANISM(S): Mus musculus 
2013-09-04 | E-GEOD-50549 | biostudies-arrayexpress
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