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ProteomicsMST4 promotes MRC2 activity to drive osteosarcoma proliferation
Osteosarcoma is one of the most common types of orthopedic malignancies with an accelerated disease progression and poor prognosis.The purpose of this study was to further investigate the function of Serine/threonine protein kinase 4(MST4) in osteosarcoma and its underlying mechanisms. The expressio...
ORGANISM(S): Homo sapiens (Human) 
2026-10-26 | PXD034216 | Pride
Mrc2 Mst4 Osteosarcoma proliferation 
ProteomicsZDHHC9 Promotes Osteosarcoma Progression via KRAS-Associated Enhancement of the RAS/MAPK Signaling Pathway
Background: Osteosarcoma, a primary malignant bone tumor predominantly affecting children and adolescents, exhibits a dismal prognosis for patients with metastatic or recurrent disease, characterized by low five-year survival rates. This poor outcome is largely attributed to the incomplete understan...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD066322 | Pride
Mapk pathway Zdhhc9 Proliferation Osteosarcoma Kras 
TranscriptomicsTranscription profiling of human PEGylated interferon-a2b treatment of one sensitive and two resistant osteosarcoma xenografts established in nude mice
Gene expression changes as a response to PEGylated interferon-a2b treatment of one sensitive and two resistant osteosarcoma xenografts established in nude mice
ORGANISM(S): Homo sapiens 
2010-04-12 | E-TABM-707 | biostudies-arrayexpress
TranscriptomicsGene expression of human paediatric osteosarcoma tumour samples relative to normal human osteoblasts
Gain or loss of genes and deregulation of gene expression can result in cumulative and progressive disruptions of normal cellular functions. Cancer-specific changes in gene expression play an essential role in cancer occurrence, and ultimately lead to cancer-related self-sufficiency in growth signal...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-12865 | biostudies-arrayexpress
TranscriptomicsCanine osteosarcoma cell lines and tissues
Cell lines and tumor tissues from canine osteosarcomas with accompanying survival and breed data. Comparisons of gene expression between osteosarcoma-derived cell lines and osteosarcoma tissues.
ORGANISM(S): Canis lupus familiaris 
2011-09-07 | E-GEOD-27217 | biostudies-arrayexpress
TranscriptomicsAtorvastatin effect on SaOS2 osteosarcoma cells
SaOS2 osteosarcoma cells were cultured with or without atorvastatin (10 µM) for 6, 15 or 24h (2 biological replcates). RNA were isolated and hybridized to RNG microarrays. Background Osteosarcoma is the most common primary tumor of bone. The rapid development of metastatic lesions and resistance to...
ORGANISM(S): Homo sapiens 
2011-02-22 | E-GEOD-24401 | biostudies-arrayexpress
TranscriptomicsDNA copy number profiling of canine osteosarcoma
Identification of DNA copy number imbalances in 22 spontaneous canine osteosarcoma cases using array comparative genomic hybridization (aCGH) analysis
ORGANISM(S): Canis familiaris 
2013-11-01 | E-MTAB-1986 | biostudies-arrayexpress
TranscriptomicsAn integrative multi-platform analysis for biomarker discovery of osteosarcoma
Three osteosarcoma (OS) cell lines (MG-63, Saos-2 and U-2 OS) and 1 osteoblastic cell line (hFOB1.19) were collected for this work. MG-63 was kindly provided by Dr. Agi Grigoriadis from University College London. Saos-2, U-2 OS and hFOB1.19 were purchased from ATCC. All cells used were kept in expon...
ORGANISM(S): Homo sapiens 
2011-09-15 | E-GEOD-14789 | biostudies-arrayexpress
TranscriptomicsExpression data from non-metastatic and metastatic osteosarcoma cells
Osteosarcoma (OS) is the malignant bone tumor with a high tendency to metastasize to the lung, where the molecular mechanisms are unclear. The mouse OS cell line LM8 has been isolated originally from the Dunn OS cell line by in vivo selection as a subline with a high metastatic potential to the lung...
ORGANISM(S): Mus musculus 
2011-03-04 | E-GEOD-26648 | biostudies-arrayexpress
TranscriptomicsExpression data from conventional osteosarcoma compared to primary non-neoplastic osteoblast cells
In osteosarcoma patients, the development of metastases, often to the lungs, is the most frequent cause of death. To improve this situation, a deeper understanding of the molecular mechanisms governing osteosarcoma development and dissemination and the identification of novel drug targets for an imp...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-14359 | biostudies-arrayexpress
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