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ProteomicsZDHHC9 Promotes Osteosarcoma Progression via KRAS-Associated Enhancement of the RAS/MAPK Signaling Pathway
Background: Osteosarcoma, a primary malignant bone tumor predominantly affecting children and adolescents, exhibits a dismal prognosis for patients with metastatic or recurrent disease, characterized by low five-year survival rates. This poor outcome is largely attributed to the incomplete understan...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD066322 | Pride
Mapk pathway Zdhhc9 Proliferation Osteosarcoma Kras 
ProteomicsASF1B promotes gastric cancer liver metastasis through inhibiting ZDHHC9/PCBP1/ SLC7A11 signaling axis mediated ferroptosis
Despite advances in comprehensive gastric cancer (GC) therapies, the prognosis of patients with liver metastasis remains poor. Identifying potential molecular targets for GC liver metastasis (GCLM) may provide new treatment avenues. Initially, clinical samples from patients with GCLM were analyzed t...
ORGANISM(S): Homo Sapiens 
PXD069269 |
GenomicsThe X-Linked Intellectual Disability gene, ZDHHC9, is important for oligodendrocyte maturation and myelin formation
The X-Linked Intellectual Disability gene, ZDHHC9, is important for oligodendrocyte maturation and myelin formation
PRJNA991995 | ENA
TranscriptomicsThe X-Linked Intellectual Disability gene, ZDHHC9, is important for oligodendrocyte maturation and myelin formation
Two percent of all patients with X-linked intellectual disability (XLID) exhibit loss-of-function mutations in the palmitoylating enzyme, ZDHHC9. One of the main anatomical deficits observed in these patients is a decrease in corpus callosum volume and a disruption of white matter integrity. We demo...
ORGANISM(S): Mus musculus 
2023-08-21 | GSE236665 | GEO
UnknownZDHHC9 promotes colon tumor growth by inhibiting effector T cells.
Not available
S-EPMC9677519 | biostudies-literature
UnknownEpilepsy, cognitive deficits and neuroanatomy in males with ZDHHC9 mutations.
Not available
S-EPMC4435709 | biostudies-literature
UnknownSystematic analysis of ZDHHC9 as a potential prognostic and immunotherapy biomarker in breast cancer.
Not available
S-EPMC12307147 | biostudies-literature
UnknownMicro-scale control of oligodendrocyte morphology and myelination by the intellectual disability-linked protein acyltransferase ZDHHC9.
Not available
S-EPMC12488188 | biostudies-literature
UnknownASF1B promotes gastric cancer liver metastasis through inhibiting ZDHHC9/PCBP1/ SLC7A11 signaling axis mediated ferroptosis.
Not available
S-EPMC12905238 | biostudies-literature
UnknownThe X-Linked Intellectual Disability Gene, ZDHHC9 , Is Important for Oligodendrocyte Subtype Determination and Myelination.
Not available
S-EPMC12121472 | biostudies-literature
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