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GenomicsTemperature-dependent alternative splicing of FLM controls flowering in Arabidopsis thaliana
How plants control the transition to flowering in response to ambient temperature is only beginning to be understood. In Arabidopsis thaliana, the MADS-box transcription factor genes FLOWERING LOCUS M (FLM) and SHORT VEGETATIVE PHASE (SVP) have key roles in this process. FLM is subject to temperatu...
ORGANISM(S): Arabidopsis thaliana 
2013-09-19 | E-GEOD-48082 | biostudies-arrayexpress
TranscriptomicsRNA at 92 M-BM-0C: the non-coding transcriptome of the hyperthermophilic archaeon Pyrococcus abyssi.
The non-coding transcriptome of the hyperthermophilic archaeon Pyrococcus abyssi is investigated using the RNA-seq technology. A dedicated computational pipeline analyzes RNA-seq reads and prior genome annotation to identify small RNAs, untranslated regions of mRNAs, and cis-encoded antisense transc...
ORGANISM(S): Pyrococcus abyssi 
2014-05-31 | E-GEOD-58131 | biostudies-arrayexpress
GenomicsGenome-wide chromatin maps of T-cell acute lymphoblastic leukemia (T-ALL) [ChIP-seq]
Here we modeled T-ALL resistance to Notch inhibition, identifying M-bM-^@M-^XpersisterM-bM-^@M-^Y cells that readily expand in the presence of gamma secretase inhibitor (GSI) and the absence of Notch signaling. Rare persister cells are already present in naM-CM-/ve T-ALL populations, and the reversi...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-54379 | biostudies-arrayexpress
ProteomicsMitochondrial reprogramming underlies resistance to BCL-2 inhibition in lymphoid malignancies
Guieze R, Liu VM, Rosebrock D, Jourdain AA, Hernandez-Sanchez M, Martinez A, Sun J, Baranowski K, Thompson PA, Heo J, Cartun Z, Aygun O, Notarangelo G, Livitz D, Li S, Hacken ET, Davids MS, Iorgelescu JB, Zhang W, Biran A, Fernandes SM, Brown JR, Ana Lako A, Ciantra ZB, Keskin DB, Udeshi ND, Wierd...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-02 | MSV000083512 | MassIVE
TranscriptomicsSpaceflight Modulates Gene Expression in Astronauts
Astronauts are exposed to a unique combination of stressors during spaceflight, which leads to alterations in their physiology and potentially increases their susceptibility to infectious pathogens. Here we report the first microarray evaluation of any astronaut tissue sample, specifically whole bl...
ORGANISM(S): Homo sapiens 
2013-10-15 | E-GEOD-47126 | biostudies-arrayexpress
TranscriptomicsGDF5 variant with superior healing capacity
Seventy-two female Sprague-Dawley rats underwent a 5 mm critical-sized femoral segmental defect followed by stabilization with a custom-made unilateral external fixator. Following femoral defect generation, absorbable type I bovine collagen sponges were loaded either with 50 ug GDF5wt or 50 ug GDF5N...
ORGANISM(S): Rattus norvegicus 
2015-01-15 | E-MTAB-2249 | biostudies-arrayexpress
TranscriptomicsGenome wide expression data from discordant twins (ulcerative colitis, primary mucosal tissue)
Background and aims. The etiopathology of inflammatory bowel diseases is still poorly understood. To date, only few little data are available on the microbiota composition in ulcerative colitis (UC), representing a major subform of inflammatory bowel diseases. Currently, one of the main challenges i...
ORGANISM(S): Homo sapiens 
2012-01-18 | E-GEOD-22619 | biostudies-arrayexpress
GenomicsA genome-wide analysis of open chromatin in human tracheal epithelial cells reveals novel candidate regulatory elements for lung function (DNase-hypersensitivity)
Distal cell-type-specific regulatory elements may be located at very large distances from the genes that they control and are often hidden within intergenic regions or in introns of other genes. The development of methods that enable mapping of regions of open chromatin genome wide has greatly advan...
ORGANISM(S): Homo sapiens 
2013-11-08 | E-GEOD-52179 | biostudies-arrayexpress
GenomicsA biophysical DNA binding model for the LEAFY transcription factor reveals the evolutionary fluidity of its binding sites
Despite great advances in sequencing capacity, generating functional information for non-model organisms remains a challenge. One solution lies in an improved ability to predict genetic circuits based on primary DNA sequence combined with the characterization of regulatory molecules from model speci...
ORGANISM(S): Arabidopsis thaliana 
2011-05-13 | E-GEOD-24568 | biostudies-arrayexpress
UnknownNovel rotatable tabletop for total-body irradiation using a linac-based VMAT technique.
Not available
S-EPMC6937701 | biostudies-literature
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