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TranscriptomicsGene expression and ChIP-chip analysis of U251 human glioblastoma cell line
Using human U251 glioblastoma cells with endogenous mutp53 expression as a model, we performed a ChIP-chip analysis of mutp53 binding sites on a custom tiling array, coupled with global expression profiling and an analysis of the epigenetic status of mutp53 regulated promoters. Mutp53 binds preferen...
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-35500 | biostudies-arrayexpress
TranscriptomicsZebrafish Light Pulse
Transcriptional profiling of light response in the zebrafish at several organizational levels: the whole animal, the organ and the cell. Exposure of larvae, heart organ cultures and cell culture cells to light pulses of 1 and 3 hours duration and measurement of changes in gene expression compared to...
ORGANISM(S): Danio rerio 
2011-03-01 | E-MTAB-381 | biostudies-arrayexpress
UnknownMassive transcriptional perturbation in subgroups of diffuse large B-cell lymphomas.
Not available
S-EPMC3817189 | biostudies-literature
TranscriptomicsMammary carcinomas in WAP-SV40 transgenic mice [gene expression]
Transgenic expression in mice of two synergistically acting SV40 early region encoded proteins, large (LT) and small (sT) tumor antigens, in the mammary epithelium recapitulates loss of p53 and Rb function and deregulation of PP2A-controlled mitogenic pathways in human breast cancer. In primiparous ...
ORGANISM(S): Mus musculus 
2012-10-31 | E-GEOD-29117 | biostudies-arrayexpress
TranscriptomicsInvoluted normal mammary gland in WAP-SV40 transgenic mice [gene expression]
Transgenic expression in mice of two synergistically acting SV40 early region encoded proteins, large (LT) and small (sT) tumor antigens, in the mammary epithelium recapitulates loss of p53 and Rb function and deregulation of PP2A-controlled mitogenic pathways in human breast cancer. In primiparous ...
ORGANISM(S): Mus musculus 
2012-10-31 | E-GEOD-33038 | biostudies-arrayexpress
UnknownThe colonic mucosa-associated microbiome in SIV infection: shift towards Bacteroidetes coincides with mucosal CD4+ T cell depletion and enterocyte damage.
Not available
S-EPMC7331662 | biostudies-literature
TranscriptomicsChIP analysis on a custom tiling array of U251 human glioblastoma cell line
Missense mutations in the TP53 gene are frequent genetic alterations in human tumor tissue and cell lines. In contrast to wild-type p53, the mutant p53 (mutp53) protein has lost the transcriptional activity towards pro-apoptotic and growth arrest genes, but retained the property to interact with DNA...
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-35453 | biostudies-arrayexpress
UnknownRetinoid homeostasis in major depressive disorder.
Not available
S-EPMC9947135 | biostudies-literature
TranscriptomicsGene expression analysis of U251 human glioblastoma cell line
The human TP53 gene is frequently mutated in tumors and cell lines. Unlike other tumor suppressors that are commonly inactivated by deletions or nonsense mutations, the majority of p53-mutations are missense point mutations that result in the expression of a full-length protein with an altered amino...
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-35454 | biostudies-arrayexpress
TranscriptomicsDKK1 expression is down-regulated in the lymph node pre-metastatic niche in esophageal cancer
Lymph node metastasis is a poor prognosis indicator in esophageal cancer. Although tumor spreading currently forms the main basis for therapy selection, the molecular mechanisms underlying the metastatic pathway remain insufficiently understood. Several studies aimed to investigate these mechanisms ...
ORGANISM(S): Homo sapiens 
2015-05-18 | E-GEOD-51021 | biostudies-arrayexpress
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