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TranscriptomicsExpression data from stimulated or unstimulated human CD4+ T cells incubated with edelfosine
The cytotoxic drug edelfosine is a synthetic analog of 2-lysophosphatidylcholine. Edelfosine is incorporated by highly proliferating cells, e.g. activated immune cells. It is unknown if the described mechanisms for edelfosine action attained by in vitro approaches exclusively contribute to the obser...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-44392 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of murine gamma delta T cells from wild type and beta2 integrin-deficient (CD18 KO) lungs
The beta2 integrin subunit (CD18) is thought to regulate gamma delta T cells in vivo. The objective of this study was to determine the gene expression changes mediated by loss of CD18 in lung gamma delta T cells. Single cell RNA sequencing was performed on gamma delta T cells (CD3+ gamma delta TCR+)...
ORGANISM(S): Mus musculus 
2020-08-14 | E-MTAB-8732 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-Seq of IFN-γ stimulated murine bone marrow-derived macrophages (BMDMs) infected Toxoplasma
To study the effect of stress on macrophages due to Toxoplasma, we stimulated murine bone marrow-derived macrophages (BMDMs) with IFN-γ (no-stimulate control) and infected them with the apicomplexan parasite Toxoplasma gondii. scRNA-Seq (10X Chromium genomics ) was performed to understand the change...
ORGANISM(S): Mus musculus 
2024-10-09 | E-MTAB-14453 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-Seq of bovine macrophage cell lines from two cow strains infected with Theileria
To understand the immune response of cows to the apicomplexan parasite Theileria annulata, we used ex vivo isolate cells derived from two infected calve : Holstein 12886 (Bos taurus), which is known to be susceptible to the disease, and Sahiwal 82H (Bos indicus), which is known to be resistant. The ...
ORGANISM(S): Bos taurus 
2024-10-09 | E-MTAB-14450 | biostudies-arrayexpress
UnknownA complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation.
Not available
S-EPMC5566957 | biostudies-literature
TranscriptomicsMammary carcinomas in WAP-SV40 transgenic mice [aCGH]
Transgenic expression in mice of two synergistically acting SV40 early region encoded proteins, large (LT) and small (sT) tumor antigens, in the mammary epithelium recapitulates loss of p53 and Rb function and deregulation of PP2A-controlled mitogenic pathways in human breast cancer. In primiparous ...
ORGANISM(S): Mus musculus 
2012-10-31 | E-GEOD-31097 | biostudies-arrayexpress
TranscriptomicsMammary carcinomas in WAP-SV40 transgenic mice [gene expression]
Transgenic expression in mice of two synergistically acting SV40 early region encoded proteins, large (LT) and small (sT) tumor antigens, in the mammary epithelium recapitulates loss of p53 and Rb function and deregulation of PP2A-controlled mitogenic pathways in human breast cancer. In primiparous ...
ORGANISM(S): Mus musculus 
2012-10-31 | E-GEOD-29117 | biostudies-arrayexpress
TranscriptomicsInvoluted normal mammary gland in WAP-SV40 transgenic mice [gene expression]
Transgenic expression in mice of two synergistically acting SV40 early region encoded proteins, large (LT) and small (sT) tumor antigens, in the mammary epithelium recapitulates loss of p53 and Rb function and deregulation of PP2A-controlled mitogenic pathways in human breast cancer. In primiparous ...
ORGANISM(S): Mus musculus 
2012-10-31 | E-GEOD-33038 | biostudies-arrayexpress
TranscriptomicsDKK1 expression is down-regulated in the lymph node pre-metastatic niche in esophageal cancer
Lymph node metastasis is a poor prognosis indicator in esophageal cancer. Although tumor spreading currently forms the main basis for therapy selection, the molecular mechanisms underlying the metastatic pathway remain insufficiently understood. Several studies aimed to investigate these mechanisms ...
ORGANISM(S): Homo sapiens 
2015-05-18 | E-GEOD-51021 | biostudies-arrayexpress
MetabolomicsChitin utilization by marine picocyanobacteria and the evolution of a planktonic lifestyle.
Marine picocyanobacteria Prochlorococcus and Synechococcus, the most abundant photosynthetic cells in the oceans, are generally thought to have a primarily single-celled and free-living lifestyle. However, while studying the ability of picocyanobacteria to supplement photosynthetic car...
2024-02-21 | MTBLS5229 | MetaboLights
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