Sort   by:  
 Page size 
ProteomicsRegulation of the endosomal SNX27 retromer by OTULIN
OTULIN specifically hydrolyzes methionine1 (Met1)-linked ubiquitin chains conjugated by LUBAC (linear ubiquitin chain assembly complex). Using mass spectrometry, we discovered an interaction of OTULIN with SNX27 (sorting nexin 27), an adaptor of the endosomal retromer complex responsible for protein...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD012082 | Pride
Acitivity-based probe Otulin Interactome 
ProteomicsA linear diubiquitin-based probe for efficient and selective detection of the deubiquitinating enzyme OTULIN
The methionine1 (M1)-specific deubiquitinase OTULIN acts as a negative regulator of NF-ΚB signaling and immune homeostasis. By replacing G76 in distal ubiquitin by dehydroalanine we designed the diubiquitin (diUb) probe UbG76Dha-Ub (OTULIN ABP) that couples to the catalytic site of OTULIN and thereb...
ORGANISM(S): Homo sapiens (Human) 
2017-09-19 | PXD006868 | Pride
Human Otulin 
ProteomicsLarge-scale proteome and ubiquitination landscape of patients with OTULIN haploinsufficiency Part1 of 3
The molecular basis of interindividual clinical variability upon infection with Staphylococcus aureus is unclear. We describe patients with haploinsufficiency for the linear deubiquitinase OTULIN, encoded on chromosome 5p. The patients suffer from episodes of life-threatening necrosis, typically tri...
ORGANISM(S): Homo sapiens (Human) 
2022-06-13 | PXD032727 | Pride
Lc-msms Tmt Otulin Ubiquitin 
GenomicsThe deubiquitinase OTULIN regulates tau expression in neurons [sAD2.1_WTC11_iPSNs]
The deubiquitinase OTULIN regulates tau expression in neurons [sAD2.1_WTC11_iPSNs]
PRJNA1248949 | ENA
GenomicsThe deubiquitinase OTULIN regulates tau expression in neurons
The deubiquitinase OTULIN regulates tau expression in neurons
PRJNA1248434 | ENA
GenomicsOtulin inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice
Otulin inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice
PRJNA746296 | ENA
GenomicsPyoderma gangrenosum caused by molecular uncoupling of OTULIN catalytic activity and LUBAC binding
Pyoderma gangrenosum caused by molecular uncoupling of OTULIN catalytic activity and LUBAC binding
PRJNA1281733 | ENA
GenomicsPyoderma gangrenosum caused by molecular uncoupling of OTULIN catalytic activity and LUBAC binding
Pyoderma gangrenosum caused by molecular uncoupling of OTULIN catalytic activity and LUBAC binding
PRJNA1281734 | ENA
TranscriptomicsThe deubiquitinase OTULIN regulates tau expression in neurons [sAD2.1_WTC11_iPSNs]
Degradation of aggregation-prone tau is regulated by the ubiquitin-proteasome system (UPS) and autophagy, which are impaired in Alzheimer’s disease (AD) and related tauopathies causing tau aggregation. Protein ubiquitination with linkage specificity determines the fate of proteins that can be either...
ORGANISM(S): Homo sapiens 
2026-03-11 | GSE294290 | GEO
ProteomicsDeubiquitinase OTULIN dampens RIG-I dependent type I IFN signaling by removing the linear ubiquitination from TRAF6
In this study, we observed a global increase in intracellular linear ubiquitination upon RNA viral infection, suggesting that linear ubiquitination may be a prerequisite for the initiation of antiviral innate immunity. Furthermore, using a combination of various cell lines and in vivo experiments, w...
ORGANISM(S): Homo Sapiens 
2025-11-15 | PXD070809 |
Sort   by:  
 Page size