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MetabolomicsThe Bardet-Biedl protein Bbs1 controls photoreceptor outer segment protein and lipid composition

Summary

Primary cilia are key sensory organelles whose dysfunction leads to ciliopathy disorders such as Bardet-Biedl syndrome (BBS). Retinal degeneration is common in ciliopathies, since the outer segments (OSs) of photoreceptors are highly specialized primary cilia. BBS...

2022-02-18 | MTBLS4013 | MetaboLights
MetabolomicsThe patatin-like protein PlpD forms novel structurally dynamic homodimers in the Pseudomonas aeruginosa outer membrane

Members of the Omp85 superfamily of outer membrane proteins (OMPs) found in Gram-negative bacteria, mitochondria and chloroplasts are characterized by a distinctive 16-stranded β-barrel transmembrane domain and at least one periplasmic POTRA domain. All previously studied Omp85 proteins promote c...

2025-12-08 | MTBLS9803 | MetaboLights
ProteomicsLFQ-proteomic on bbs1 zebrafish photoreceptor outer segments
Bardet-Biedl syndrome (BBS) is a ciliopathy characterized by retinal dystrophy, intellectual disability, polydactyly, obesity and renal anomalies. In photoreceptors (PR), light sensation occurs in outer segments (OSs), which are specialized primary cilia. BBS1, the major BBS gene, is part of a prote...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2022-02-10 | PXD026646 | Pride
Lfq-p Zebrafish Outer segment Photoreceptor Bbs 
TranscriptomicsConditional knockdown of DNA methyltransferase-1 (Dnmt1) reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis
To explore the epigenetic contribution to retinal development, we generated conditional knockout alleles of DNA methytransferase-1 (Dnmt1) mediated by Rx-Cre in mice. The results demonstrate a unique function of DNMT1-mediated DNA methylation in controlling RPE apicobasal polarity and neural retina...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43951 | biostudies-arrayexpress
ProteomicsPROTEOME OF BOVINE MITOCHONDRIA AND ROD OUTER SEGMENT DISKS: COMMONALITIES AND DIFFERENCES.
The retinal rod outer segment (OS) isa stack of diskssurrounded by the plasma membrane,housing proteins related to phototransduction as well asmitochondrial proteins involved in oxidative phosphorylation (OxPhos). This prompted us to compare the proteome of bovine OS disks and mitochondria, to asses...
ORGANISM(S): Bos taurus (Bovine) 
2022-03-01 | PXD008087 | Pride
Atp synthase  disks electron transfer chain  mass spectrometry  mitochondria  oxidative phosphorylation  rod outer segment  transmission electron microscopy. 
ProteomicsProteomic profiling of plasma membrane proteins from bovine rod photoreceptor outer segments
The outer segment (OS) organelle of vertebrate photoreceptors is a highly specialized cilium whose plasma membrane plays vital and diverse roles in supporting photoreceptor function and health. However, little is known about the identity of its protein constituents, as this membrane cannot be purifi...
ORGANISM(S): Bos taurus (Bovine) Mus musculus (Mouse) 
2021-04-30 | PXD022864 | Pride
Protein correlation profiling Retina Outer segment Photoreneptor 
ProteomicsRab28 is localised to photoreceptor outer segments, regulates outer segment shedding but is not linked to retinal degeneration in zebrafish
The photoreceptor outer segment is the canonical example of a modified and highly specialised cilium, with an expanded membrane surface area in the form of discs or lamellae for efficient light detection. Many ciliary proteins are essential for normal photoreceptor function and cilium dysfunction of...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2020-04-09 | PXD017523 | Pride
Retinal degeneration Cone-rod dystrophy Rab28 Rpe Zebrafish Phototransduction cascade 
TranscriptomicsTranscription profiling of three developmental stages of the outer layer of hemp (Cannabis sativa) stems
Three 2cm segments were excised from different parts (TOP, MID, BOT) along the vertical axis of a 4 week old stem of hemp (C. sativa), and the outer layers of the stem were compared using a cDNA amplicon array. Each segment represented a different developmental stage, especially in relation to bast ...
ORGANISM(S): Cannabis sativa 
2007-07-01 | E-MEXP-1042 | biostudies-arrayexpress
ProteomicsSimultaneous absolute quantification of multiple proteins from the photoreceptor outer segment
This data set provides most accurate absolute quantification of outer segment proteins of rod photoreceptors of retina.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-12-12 | MSV000090885 | MassIVE
ProteomicsCiliary tip actin dynamics regulate the cadence of photoreceptor disc formation
As signalling organelles, primary cilia regulate their membrane G protein-coupled receptor (GPCR) content by ectocytosis, a process requiring localised actin dynamics at their tip to alter membrane shape.1,2 Mammalian photoreceptor outer segments comprise an expanse of folded membranes (discs) at th...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-08 | PXD038015 | Pride
Lc-ms Cilia Retina 
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