Oxphos complex - OmicsDI

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Instrument Platform

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Gas Chromatography MS - positive (1)

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CHEBI ID

CHEBI:15891 (3)
CHEBI:18012 (3)
CHEBI:18261 (3)
CHEBI:184023 (3)
CHEBI:15354 (2)
CHEBI:15428 (2)
CHEBI:15698 (2)
CHEBI:15727 (2)
CHEBI:15887 (2)
CHEBI:16113 (2)
CHEBI:16238 (2)
CHEBI:16264 (2)
CHEBI:16335 (2)
CHEBI:16704 (2)
CHEBI:16708 (2)
CHEBI:16737 (2)
CHEBI:16750 (2)
CHEBI:16865 (2)
CHEBI:16919 (2)
CHEBI:16958 (2)
CHEBI:17015 (2)
CHEBI:17053 (2)
CHEBI:17154 (2)
CHEBI:17172 (2)
CHEBI:17202 (2)
CHEBI:17295 (2)
CHEBI:17310 (2)
CHEBI:17368 (2)
CHEBI:17562 (2)
CHEBI:17596 (2)

Metabolite Name

Adenine (2)
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Argininosuccinic acid (2)
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Creatine (2)
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Inosine (2)
L-Anserine (2)
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Taurine (2)
UDP-N-acetylglucosamine (2)
Uridine (2)
(-)-Riboflavin (1)
(R)-2-Hydroxyglutarate (1)
(S)-Homostachydrine (1)
(¡À)11(12)-EET (1)
1,2,3,4,Tetrahydro-1,5,7-trimethylnapthalene (1)
1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene (1)
1,3-Butadiene (1)

First Public Date

2023 (22)
2024 (20)
2025 (14)
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2020 (6)
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2014 (4)
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Modification

2x(15)N labeled L-lysine (2)
4x(15)N labeled L-arginine (2)

Study type

Transcription profiling by array (16)
RNA-seq of coding RNA (10)
ChIP-seq (3)
Unknown experiment type (1)
RNA-seq of coding RNA from single cells (1)

Release Date

2023 (75)
2022 (74)
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2024 (62)
2020 (44)
2019 (35)
2018 (35)
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Lab affiliation

Dpt. of Immunobiology University of Lausanne (UNIL), Boveresses 155 CH-1066 Epalinges (4)
Center for Molecular Biology of Heidelberg University (ZMBH), 69120 Heidelberg, Germany (2)
Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, Australia (2)
Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, Australia. (2)
Karolinska Institutet, Stockholm, Sweden (2)
Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention, No. 8, Longyuan Road, Nanshan District, Shenzhen, China 518055. (2)
Laboratory of Bioenergetics, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic (2)
Structural Biology Group, European Synchrotron Radiation Facility (ESRF), Grenoble, France (2)
Utrecht University (2)
-Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia -School of Pharmacy and Biomedical Sciences, Curtin University, Bentley, Western Australia 6102, Australia -Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6102, Australia (1)
-Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, Western Australia 6009, Australia -Centre for Medical Research, The University of Western Australia, QEII Medical Centre, Nedlands, Western Australia 6009, Australia -School of Molecular Sciences, The University of Western Australia, Crawley, Western Australia 6009, Australia (1)
1.School of Life and Environmental Sciences, Faculty of Science, Engineering and Built Environment, Deakin University, Geelong 3216, Australia 2.Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, 3168 Melbourne, Australia 3.Department of Molecular and Translational Science, Monash University, 3168 Melbourne, Australia (1)
ARC Centre of Excellence in Plant Energy Biology at The University of Western Australia (1)
Assistant Professor Department of Pathology University of South Alabama Mobile, Alabama United States (1)
Assistant professor, School of Biological Sciences, Seoul National University (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht (1)
CNIC (1)
Cardiovascular and Metabolic Diseases, Duke-NUS Medical School, Singapore (1)
Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV) (1)
Centro de Biologia Molecular Severo Ochoa Spanish Research Council Nicolas Cabrera,1 28049 Madrid (Spain) (1)
Centro de Biología Molecular Severo Ochoa Spanish Research Council Nicolas Cabrera, 1 28049 Madrid (Spain) (1)
Charité – Universitätsmedizin Berlin, Institute of Medical Genetics and Human Genetics, 13353 Berlin, Germany. (1)
Clinical Research Division, Fred Hutchinson Cancer Research Center (1)
David Meierhofer, MS facility, Max Planck Institute for Molecular Genetics, Berlin-Dahlem, Germany ( lab head ) (1)
Departamento de Biología Celular. Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional.Avenida Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Alcaldía Gustavo A. Madero, Ciudad de México, Código Postal 07360. (1)
Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico. (1)
Department of Biochemistry & Pharmacology, Bio21 Institute, University of Melbourne (1)
Department of Biochemistry and Molecular Biology Bio21 Molecular Science & Biotechnology Institute and The University of Melbourne 30 Flemington Road, Parkville VIC 3052 Australia (1)
Department of Biochemistry and Molecular Biology Bio21 Molecular Science and Biotechnology Institute Third floor, room 368 The University of Melbourne Victoria 3010 Australia (1)
Department of Biochemistry and Molecular Biology, Mitochondria lab, Monash University, Clayton 3800, Australia (1)

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OXPHOS complex I deficiency leads to transcriptional changes of the Nrf2-Keap1 pathway and selenoproteins.

Defective complex I (CI) is the most common type of oxidative phosphorylation (OXPHOS) disease in patients, with an incidence of 1 in 5,000 live births. Complex I deficiency can present in infancy or early adulthood and shows a wide variety of clinical manifestations, including Leigh syndrome, (card...

ORGANISM(S): Homo sapiens

2011-11-01 | E-GEOD-27041 | biostudies-arrayexpress

Label-free global proteome profiling of European American and African American bladder tumor patients.

Bladder cancer (BLCA) mortality is higher in African American (AA) patients compared to their European American (EA) counterparts, but the molecular mechanism underlying differences are unknown. . Thus, we performed proteomics analysis of AA and EA BLCA and identified higher mitochondrial OXPHOS spe...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2024-08-08 | MSV000095559 | MassIVE

Complex II assembly drives metabolic adaptation to OXPHOS dysfunction

During acute oxidative phosphorylation (OXPHOS) dysfunction, the reverse activity of succinate dehydrogenase (Complex II) maintains the redox state of the Coenzyme Q pool by utilizing either fumarate or oxygen as terminal electron acceptors. The tendency for one over another has been suggested to be...

ORGANISM(S): Homo sapiens (Human)

2025-06-06 | PXD064653 | Pride

Complex II assembly drives metabolic adaptation to OXPHOS dysfunction

ORGANISM(S): Homo sapiens (Human)

2025-06-06 | PXD064649 | Pride

Mitochondria Tca cycle Oxphos Sdh

Complex II assembly drives metabolic adaptation to OXPHOS dysfunction

ORGANISM(S): Homo sapiens (Human)

2025-06-06 | PXD064658 | Pride

Mitochondria Tca cycle Oxphos Sdh

Complex II assembly drives metabolic adaptation to OXPHOS dysfunction.

ORGANISM(S): Homo sapiens (Human)

2025-06-06 | PXD064675 | Pride

Mitochondria Tca cycle Oxphos Sdh

Type 1 interferons induce changes in core metabolism that are critical for immune function

Type 1 interferons (IFNs) induce complex responses that can be beneficial or deleterious, depending on context. Greater understanding of the mechanisms of action of these cytokines could allow new therapeutic approaches. We found that type 1 IFNs induced changes in cellular metabolism that were cr...

ORGANISM(S): Mus musculus

2016-07-01 | E-GEOD-81889 | biostudies-arrayexpress

OXPHOS complex deficiency in congenital myopathy: A systematic review.

Not available

S-EPMC12517249 | biostudies-literature

Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer.

Not available

S-EPMC7691450 | biostudies-literature

HADHA Regulates Respiratory Complex Assembly and Couples FAO and OXPHOS.

Not available

S-EPMC11653673 | biostudies-literature

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