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ProteomicsM9-00308-MCP - Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition
Phosphopeptides enriched from M- phase and C-phase arrested SILAC-labeled Hela S3 cells
ORGANISM(S): Homo sapiens (Human) 
2011-04-15 | PRD000146 | Pride
ProteomicsPlasma Proteomics Reveal COVID-19 Associated Network and Severity Biomarkers
Coronavirus disease 2019 (COVID-19) has been threatening public health for the last 3 years globally. So far, the pathophysiology of the disease and therapeutic strategies have not clearly known yet. In this project, performing label-free plasma proteomics analysis, we aimed at identifying severity ...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2023-03-11 | PXD031813 | Pride
Severity biomarkers Covid-19 associated network Label-free quantification Covid-19 disease Mass-spectrometry based plasma proteomics 
ProteomicsQuantitative proteomics identifies secreted diagnostic biomarkers as well as tumor-dependent prognostic targets for clear cell Renal Cell Carcinoma
Clear cell Renal Cell Carcinoma (ccRCC) is the third most common and most malignant urological cancer, with a 5-year survival rate of 10% for patients with advanced tumors. Here, we identified 10,160 unique proteins by in-depth quantitative proteomics, of which 955 proteins were significantly regula...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD024696 | Pride
Proteomics Urine Biomarkers Renal cell carcinoma Drug repurposing 
ProteomicsQuantitative phosphoproteomics analysis uncovers CDK1- and PAK2-mediated malignant signaling pathways in clear cell Renal Cell Carcinoma
Clear cell Renal Cell Carcinoma (ccRCC) is among the 10 most common cancers and causes more than 140,000 deaths worldwide every year. In order to elucidate the underlying molecular mechanisms orchestrated by phosphorylation modifications, we performed a comprehensive quantitative phosphoproteomics c...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD028428 | Pride
Biomarkers Signaling pathways Drug targets Phosphoproteomics Renal cell carcinoma 
ProteomicsIdentification of the cell cycle specific proximal interactors of PCDH7
We used proximity dependent biotin identification (BioID) method to determine cell cycle specific interaction partners of PCDH7. HeLa S3 cells were synchronized to interphase and mitosis using double tymidine block and double thymidine block followed by S-Trityl-L-cysteine (STC) treatment respecti...
ORGANISM(S): Homo sapiens (Human) 
2023-02-27 | PXD029246 | Pride
Pcdh7 Mitosis Hela Homo sapiens Cell cycle Bioid Protocadherin 
ProteomicsProximal Biotinylation Based Combinatory Approach for Isolating Plasma Membrane Proteins
Comprehensive profiling of the cell surface proteome has been challenging due to the lack of tools for an effective and reproducible way to isolate plasma membrane proteins from mammalian cells. Here, we employ a proximity-dependent biotinylation approach to label and isolate plasma membrane protein...
ORGANISM(S): Homo sapiens (Human) 
2020-08-28 | PXD018383 | Pride
Sucrose density fractionation Cell surface Biotinylation Plasma membrane 
ProteomicsProximity labelling and SILAC based proteomic approach identifies proteins at the interface of homotypic and heterotypic cancer cell interactions.
Cell-cell interactions are critical for the growth of organisms and maintaining homeostasis. In the tumor microenvironment, these interactions promote cancer progression. Given their importance in healthy and diseased conditions, we have developed a method to analyze the cell-to-cell interactome. Ou...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD060134 | Pride
Silac based  proteomics Nano lc-ms/ms orbitap Cell-cell interactions 
ProteomicsProximity labelling and SILAC based proteomic approach identifies proteins at the interface of homotypic and heterotypic cancer cell interactions.
Cell-cell interactions are critical for the growth of organisms and maintaining homeostasis. In the tumor microenvironment, these interactions promote cancer progression. Given their importance in healthy and diseased conditions, we have developed a method to analyze the cell-to-cell interactome. Ou...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD052917 | Pride
Silac based  proteomics Nano lc-ms/ms orbitap Cell-cell interactions 
ProteomicsProximity labelling and SILAC based proteomic approach identifies proteins at the interface of homotypic and heterotypic cancer cell interactions.
Cell-cell interactions are critical for the growth of organisms and maintaining homeostasis. In the tumor microenvironment, these interactions promote cancer progression. Given their importance in healthy and diseased conditions, we have developed a method to analyze the cell-to-cell interactome. Ou...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD052746 | Pride
Silac based Orbitrap Hrp Cell-cell interactions 
ProteomicsSystems level analysis of epithelial to mesenchymal transition reveals more alteration in phosphoproteome than proteome and identifies DNAJB4 and CD81 as EMT regulators
We quantified protein expression changes between epithelial and mesechymal stages in immortalized human mammary epithelial cells (HMLE). Epithelial–mesenchymal transition is induced by expressing an EMT-TF, Twist.
ORGANISM(S): Homo sapiens (Human) 
2019-06-24 | PXD012001 | Pride
Emt 
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