Sort   by:  
 Page size 
TranscriptomicsSlicing-Independent RISC Activation Requires the Argonaute PAZ Domain
Small RNAs regulate the genetic networks through a ribonucleoprotein complex called the RNA induced silencing complexes (RISC), which in mammals contains at its center one of four Argonaute proteins (Ago1-4). A key regulatory event in the RNAi and miRNA pathways is Ago loading, where double stranded...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-39146 | biostudies-arrayexpress
ProteomicsInteractions of human norovirus capsid P domain with histo-blood group antigens with Hydrogen-Deuterium Exchange Mass Spectrometry
Attachment of human noroviruses to histo blood group antigens (HBGAs) is essential for infection, but how this binding event promotes the infection of host cells is unknown. Here, we employed protein NMR experiments supported by mass spectrometry and crystallography to study HBGA binding to the P ...
ORGANISM(S): Norwalk virus Norovirus Hu/GII/JP/2015/GII.P17_GII.17/Kawasaki308 Norovirus Hu/GII.4/MI001/2011/USA Norovirus Hu/GII-4/Saga4/2006/JP 
2019-03-20 | PXD011914 | Pride
Hdx ms P domain Gii.4 saga Human norovirus Histo-blood group antigens 
GenomicsEDC4 C-terminal domain scaffolds P-body assembly and links P-body dynamics to p53 mediated tumor suppression
EDC4 C-terminal domain scaffolds P-body assembly and links P-body dynamics to p53 mediated tumor suppression
PRJNA1164755 | ENA
GenomicsThe RelA hydrolase domain acts as a molecular switch for (p)ppGpp synthesis
The RelA hydrolase domain acts as a molecular switch for (p)ppGpp synthesis
PRJNA632006 | ENA
TranscriptomicsExpression quantitative trait loci (eQTL) analysis of Brassica rapa under varying soil phosphorus (P) supplies
The aim of this study was to identify eQTL in Brassica rapa grown under altered soil phosphorus (P) supply, to understand better the genetic architecture of P-use efficiency (PUE) in plants. Recombinant inbred lines (RILs) of the BraIRRI mapping population were grown at adequate and growth-limiting ...
ORGANISM(S): Brassica rapa 
2011-06-29 | E-GEOD-27052 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile Lactobacillus plantarum WCFS1 : p-coumaric acid (p-CA) treated cells
Whole genome transcriptional profiling was used to characterize the response of Lactobacillus plantarum WCFS1 human isolate during challenge with p-coumaric acid (p-CA). Twelve independent experiments were performed and mixed at random in groups of four for total of three RNA samples. The transcript...
ORGANISM(S): Lactobacillus plantarum 
2013-01-16 | E-GEOD-40126 | biostudies-arrayexpress
TranscriptomicsCSR-1 and P granules suppress sperm-specific transcription in the C. elegans germline
P granules in C. elegans are required for fertility and function to maintain germ cell identity and pluripotency.  Sterility in the absence of P granules is often accompanied by the mis-expression of soma-specific proteins and the initiation of somatic differentiation in germ cells.  To investigate ...
ORGANISM(S): Caenorhabditis elegans 
2015-05-20 | E-GEOD-67954 | biostudies-arrayexpress
TranscriptomicsGene Expression Analysis of Human Endometrial Endothelial Cells Exposed to o,p'-DDT
The endocrine disrupting chemical o,p'-DDT can affect reproductive organs, tissues and cells in several species. Treatment of human endometrial endothelial cells (HEEC) with 50 µM o,p'-DDT decreased the cell proliferation compared to the control. Microarray analyses revealed that o,p'-DDT affected b...
ORGANISM(S): Homo sapiens 
2007-10-10 | E-GEOD-9252 | biostudies-arrayexpress
ProteomicsStructure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism
Rho GTPases regulate actin dynamics and cell motility, and their hyperactivation drives cancer metastasis1. P-Rex (PI(3,4,5)P3-dependent Rac Exchanger) guanine nucleotide exchange factors (GEFs) are potent on-switches for Rho GTPase signalling and are frequently dysregulated in metastatic cancer2. P...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD034327 | Pride
Cancer Rac1 Cryo-em P-rex1 Metastasis 
TranscriptomicsP. falciparum Complicated Malaria: Modulation and Connectivity between Exportome and Variant Surface Gene Families
In temperate and sub-tropical regions of Latin America, complicated malaria manifested as hepatic dysfunction or renal dysfunction is seen in all age groups. There has been a concerted focus on understanding the patho-physiological and molecular basis of complicated malaria in children, much less is...
ORGANISM(S): Plasmodium falciparum 
2015-07-07 | E-GEOD-59844 | biostudies-arrayexpress
Sort   by:  
 Page size