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ProteomicsStructural analysis of the PTEN:P-Rex2 signaling node reveals how cancer-associated mutations coordinate to hyperactivate Rac1
The PTEN:P-Rex2 complex is a commonly mutated signaling nodes in metastatic cancer. The dual-specificity phosphatase PTEN canonically functions as a tumour suppressor by hydrolysing PI(3,4,5)P3 to PI(4,5)P2 to inhibit PI3K-AKT signaling. P-Rex2 is a RhoGTPase guanine nucleotide exchange factor activ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD021126 | Pride
Cancer P-rex2 Pten Crosslinking mass spectrometry Metastasis 
UnknownP-Rex2 regulates Purkinje cell dendrite morphology and motor coordination.
Not available
S-EPMC2393786 | biostudies-literature
UnknownP-Rex2 mediation of synaptic plasticity contributes to bone cancer pain.
Not available
S-EPMC8891909 | biostudies-literature
UnknownP-Rex2 suppresses glucose uptake into liver and skeletal muscle through different adaptor functions.
Not available
S-EPMC12325715 | biostudies-literature
UnknownP-Rex2 exhibits unique structural features and regulatory mechanisms distinct from the closely related RhoGEF P-Rex1.
Not available
S-EPMC12803288 | biostudies-literature
UnknownRegulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.
Not available
S-EPMC3890808 | biostudies-literature
UnknownStructural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP3.
Not available
S-EPMC7337056 | biostudies-literature
TranscriptomicsExpression data from Suv420h1 knockout and mutant PREX2 expressing MEFs (mouse embryonic fibroblasts)
PREX2 truncating mutations occur in melanoma. We used microarray based gene expression profiling to compare expression patterns between cells harboring Suv420h1 knockout and PREX2 mutant expressing Spontaneously immortalized MEFs from either wt or Suv420h1 knockout mice were used. Wt MEFs were trans...
ORGANISM(S): Mus musculus 
2016-04-06 | E-GEOD-57310 | biostudies-arrayexpress
UnknownCryo-electron microscopy structure of autoinhibited P-Rex2
Not available
EMPIAR-13635 | biostudies-other
UnknownRegulation and function of P-Rex family Rac-GEFs.
Not available
S-EPMC4601503 | biostudies-literature
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