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TranscriptomicsTranscriptional Profiling Defines the Roles of ERK and p38 Kinases in Epidermal Keratinocytes
Epidermal keratinocytes respond to extracellular influences by activating cytoplasmic signal transduction pathways that change the transcriptional profiles of affected cells. To define responses to two such pathways, p38 and ERK, we used SB203580 and PD98059 as specific inhibitors, and identified th...
ORGANISM(S): Homo sapiens 
2013-09-05 | E-GEOD-50591 | biostudies-arrayexpress
TranscriptomicsTranscription of Tnfaip3 is regulated by NF-kB and p38 via C/EBPβ in activated macrophages
Macrophages play a pivotal role in the immune system through recognition and elimination of microbial pathogens. Toll-like receptors (TLRs) on macrophages interact with microbial substances and initiate signal transduction through intracellular adapters. TLR4, which is important for the response to ...
ORGANISM(S): Mus musculus 
2015-04-28 | E-GEOD-46361 | biostudies-arrayexpress
TranscriptomicsSex-specific control of CNS autoimmunity by p38 MAPK signaling in myeloid cells
Objective: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), characterized by a global increasing incidence driven by relapsing-remitting disease in females. p38 MAP kinase (MAPK) has been described as a key regulator of inflammatory respons...
ORGANISM(S): Mus musculus 
2013-10-29 | E-GEOD-51707 | biostudies-arrayexpress
TranscriptomicsWhole genome analysis of p38 SAPK-mediated gene expression upon stress
Cells have the ability to respond and adapt to environmental changes through the activation of stress-activated protein kinases (SAPKs). Although it has been shown that p38 SAPK signalling participates in the regulation of gene transcription, there is not a comprehensive genome-wide transcription st...
ORGANISM(S): Mus musculus 
2010-09-29 | E-GEOD-18320 | biostudies-arrayexpress
Proteomicsp38-MAPK mediated rRNA processing and translation regulation enables PrE differentiation during mouse blastocyst maturation
p38-MAPKs are stress activated kinases necessary for placental development and nutrient and oxygen transfer during murine post-implantation development. In preimplantation development, p38-MAPK activity is required for blastocyst formation. Additionally, we have previously reported its role in regul...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-28 | PXD025711 | Pride
Lc-msms P38-mapk Phosphoproteomics Human 
ProteomicsInhibition of Cardiac p38 Highlights the Role of the Phosphoproteome in Heart Failure Progression
We employed a guinea pig model of heart failure (HF) that combines ascending aortic constriction with daily administration of the β-adrenergic agonist isoproterenol (1 mg/kg/day for 1 hour) via an implanted programmable pump. The experimental groups included: 1) Sham-operated controls; 2) ACi (Aorti...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2025-09-08 | PXD058012 | Pride
Heart failure Guinea pig Heart P38 inhibition Tmt Lc-ms/ms 
TranscriptomicsTranscriptional signature of wounded keratinocytes reveals selective roles for ERK1/2, P38 and PI3K signalling pathways
Covering denuded dermal surface after injury requires migration, proliferation and differentiation of skin keratinocytes. To clarify the major traits controlling these intermingled biological events, we surveyed the genomic modifications occurring during the course of a scratch closure of cultured h...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-6820 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human articular osteoarthritic chondrocytes after stimulation with IL-1beta and p38 MAPK inhibition with SB203580 or Birb 796
Effect of stimulation with IL-1beta and p38 MAPK inhibition with SB203580 or Birb 796 on human articular osteoarthritic chondrocytes
ORGANISM(S): Homo sapiens 
2009-11-01 | E-MEXP-1434 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat fibroblast-like synoviocyte cell cultures treated with TNFa and SB203580
Gene expression affected by TNFa was investigated, then, p38 inhibitor SB203580 was used to investigate p38 signal pathway. Experiment Overall Design: Fibroblast-like synoviocyte culture was treated with TNFa in the presence and absence of SB203580 and compared to the gene expression not treated wi...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7826 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human T24 bladder cancer cells in response to hypericin-mediated photodynamic therapy in the absence or presence of the p38 MAPK inhibitor PD169316
Study of the gene expression of T24 bladder cancer cells in response to hypericin-mediated photodynamic therapy in the absence or presence of the p38 MAPK inhibitor PD169316
ORGANISM(S): Homo sapiens 
2007-10-01 | E-MEXP-1220 | biostudies-arrayexpress
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