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ProteomicsProteomic Analysis and Functional Characterization of P4-ATPase Phospholipid Flippases from Murine Tissues
P4-ATPases are a subfamily of P-type ATPases that flip phospholipids across membranes to generate lipid asymmetry, a property vital to many cellular processes. Mutations in several P4-ATPases have been linked to severe neurodegenerative and metabolic disorders. Most P4-ATPases associate with one of...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-20 | PXD009143 | Pride
Lc-ms/ms P4-atpases Affinity chromatography Tmem30a Phospholipid flippases Cdc50a Mouse tissues 
ProteomicsProteomic analysis of the rat canalicular membrane reveals expression of a complex system of P4-ATPases in liver
Transport processes in the canalicular membrane are key elements in bile formation and are the driving force of the enterohepatic circulation of bile salts. The canalicular membrane is constantly exposed to the detergent action of bile salts. One potential element protecting the canalicular membrane...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-07-05 | PXD003299 | Pride
Cell localization Proteomics Immunohistochemistry Phospholipid homeostasis 
UnknownP4 ATPases: flippases in health and disease.
Not available
S-EPMC3645723 | biostudies-literature
UnknownP4-ATPases as Phospholipid Flippases-Structure, Function, and Enigmas.
Not available
S-EPMC4937031 | biostudies-literature
UnknownSubstrates, regulation, cellular functions, and disease associations of P4-ATPases.
Not available
S-EPMC11775268 | biostudies-literature
UnknownPhospholipid flipping involves a central cavity in P4 ATPases.
Not available
S-EPMC5732287 | biostudies-literature
UnknownThe N- or C-terminal cytoplasmic regions of P4-ATPases determine their cellular localization.
Not available
S-EPMC7530900 | biostudies-literature
UnknownYeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs.
Not available
S-EPMC6369285 | biostudies-literature
UnknownAminoglycerophospholipid flipping and P4-ATPases in Toxoplasma gondii.
Not available
S-EPMC7949121 | biostudies-literature
ProteomicsIdentification of P4-ATPase Phospholipid Flippases in Red Blood Cells and Functional Analysis of Disease-associated Mutants
ATP-dependent phospholipid flippase activity crucial for generating lipid asymmetry in membranes was first detected in red blood cells (RBCs), but the P4-ATPases responsible have not been directly determined. Using affinity-based mass spectrometry, we show that ATP11C is the only abundant P4-ATPase...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-03-08 | PXD011841 | Pride
Lc-ms/ms P4-atpases Affinity chromatography Phospholipid flippases Red blood cells Disesaes-associated mutations 
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