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ProteomicsBiotransformation of efavirenz and proteomic analysis of P450s and UGTs in human, mouse, and macaque brain-derived in vitro systems
Antiretroviral drugs such as efavirenz (EFV) are essential to combat HIV infection in the brain, but little is known about how these drugs are metabolized locally. In this study, the cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT)-dependent metabolism of EFV was probed in brain microsom...
ORGANISM(S): 9606 
2022-10-24 | MSV000090576 | MassIVE
ProteomicsCytochrome P450s protect against oxidative damage via a preferred orientation of the heme cofactor
Cytochrome P450 enzymes (P450s) are a superfamily of monooxygenases that utilise a cysteine thiolate ligated heme moiety to perform a wide range of demanding oxidative transformations. Given the oxidative power of active intermediate formed within P450s during their active cycle, it is remarkable th...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030867 | Pride
Glycopeptide antibiotic (gpa) biosynthesis Cytochrome p450s 
GenomicsNovel P450s from Antarctica
Exploration of novel P450s in Antarctica through metagenomics
PRJNA979899 | ENA
GenomicsNovel P450s from extreme regions of Turkey
Novel P450s from extreme regions of Turkey
PRJNA979897 | ENA
UnknownStructural diversity of eukaryotic membrane cytochrome p450s.
Not available
S-EPMC3682514 | biostudies-literature
UnknownThe Multifarious Link between Cytochrome P450s and Cancer.
Not available
S-EPMC6964729 | biostudies-literature
UnknownRecombinant production of eukaryotic cytochrome P450s in microbial cell factories.
Not available
S-EPMC5835717 | biostudies-literature
UnknownStructural differences between soluble and membrane bound cytochrome P450s.
Not available
S-EPMC4190058 | biostudies-literature
UnknownSimilarities, variations, and evolution of cytochrome P450s in Streptomyces versus Mycobacterium.
Not available
S-EPMC6408508 | biostudies-literature
ProteomicsProteome analysis of B. bassiana
The enzymes involved (P450s) remain mostly hidden when using microbial cell factories. In this respect, we aimed to identify P450s, which are responsible for the oxyfunctionalization of DCF (1) and (R)-2-phenoxypropionic acid (POPS) in B. bassiana using omics studies.
ORGANISM(S): Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus) (Tritirachium shiotae) 
2019-06-12 | PXD009664 | Pride
Beauveria bassiana P450s Nsaids 
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