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GenomicsTfe3-bound regions in naive pluripotent mouse embryonic stem (ES) cells
The bHLH transcription factor Tfe3 is a powerful regulator of pluripotency and we report a genome-wide analysis of Tfe3 occupancy in mouse ES cells. Nuclear localization of Tfe3 is inhibited by a protein complex containing the tumor-suppressor Folliculin (Flcn) and we also determine Tfe3 binding sit...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-39815 | biostudies-arrayexpress
UnknownA simple and highly efficient method for multi-allelic CRISPR-Cas9 editing in primary cell cultures.
Not available
S-EPMC7685144 | biostudies-literature
UnknownKAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma.
Not available
S-EPMC12064679 | biostudies-literature
TranscriptomicsGenome-wide CRISPR-Cas9 screens reveal loss of redundancy between PKMYT1 and WEE1 in Glioblastoma stem-like cells
To identify new therapeutic targets for Glioblastoma (GBM), we performed genome-wide CRISPR-Cas9 "knockout" (KO) screens in patient-derived GBM stem-like cells (GSCs) and human neural stem/progenitors (NSCs), non-neoplastic stem cell controls, for genes required for their in vitro growth. ...
ORGANISM(S): Homo sapiens 
2016-02-15 | E-GEOD-70038 | biostudies-arrayexpress
UnknownGenome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells.
Not available
S-EPMC4691575 | biostudies-literature
UnknownPan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism.
Not available
S-EPMC6003503 | biostudies-literature
ProteomicsCellular heterogeneity and therapeutic response profiling of IDH-wildtype glioma stem cell cultures
Gliomas are the most common type of primary malignant adult brain tumor. They appear to originate from neuroglial stem or progenitor cells, and are therapeutically challenging due to an invasive growth pattern and the absence of effective therapies. We have analyzed cellular, molecular and proteomic...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD035886 | Pride
Cancer Stem cell Phopshoproteomics Glioblastoma Tumor 
UnknownCellular heterogeneity and therapeutic response profiling of human IDH + glioma stem cell cultures.
Not available
S-EPMC12830798 | biostudies-literature
UnknownCellular heterogeneity and therapeutic response profiling of human IDH+ glioma stem cell cultures.
Not available
S-EPMC12324346 | biostudies-literature
UnknownNeural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma.
Not available
S-EPMC8186478 | biostudies-literature
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