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ProteomicsProteomics Reveals Altered Lipid Biosynthesis and Keratin Hyperphosphorylation in Pachyonychia Congenita
Pachyonychia congenita (PC) is a rare and painful skin disorder caused by dominant mutations in keratin genes (KRT6A/KRT6B/KRT6C/KRT16/KRT17), with no effective treatment. We developed a scalable, in-depth and miniaturized MS-based proteomics and phospho-proteomics analysis of full-thickness skin bi...
ORGANISM(S): Homo sapiens (Human) 
2026-01-14 | PXD067480 | Pride
Proteomics Skin Keratins Pachyonychia congenita Phosphoproteomics 
ProteomicsCellular heterogeneity and therapeutic response profiling of IDH-wildtype glioma stem cell cultures
Gliomas are the most common type of primary malignant adult brain tumor. They appear to originate from neuroglial stem or progenitor cells, and are therapeutically challenging due to an invasive growth pattern and the absence of effective therapies. We have analyzed cellular, molecular and proteomic...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD035886 | Pride
Cancer Stem cell Phopshoproteomics Glioblastoma Tumor 
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