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ProteomicsProteomics analysis of muscles from long lived O1/O3 flies in young and old age (Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populations) Liam C. Hunt, Jianqin Jiao, Yong-Dong Wang, David Finkelstein, Deepti Rao, Michelle Curley, Maricela Robles-Murguia, Abbas Shirinifard, Vishwajeeth R. Pagala, Junmin Peng, Yiping Fan, and Fabio Demontis. Genome Research In press 2019.
Protein expression profiles in the whole tissue lysate extracted from the thorax of O1 and O3 long-lived flies with the control B3 strain flies and analyzed by tandem mass tag (TMT)–based mass spectrometry.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-06-13 | PXD014223 | Pride
Genomic analyses of aging  evolution of aging  circadian muscle transcriptome  longevity  circadian cycle  skeletal muscle  sarcopenia  proteostasis  timeless  drosophila 
ProteomicsIdentification of JARID2/PRC2 interactome in human embryonic stem cells
JARID2 is an integral subunit of the chromatin modifier PRC2 (Polycomb Repressive Complex 2). PRC2 methylates lysine 27 in histone H3 and is required for human development. Mutaitons of PRC2 subunits have been frequently found in a variety of adult and pediatric cancer, suggesting that PRC2 critical...
ORGANISM(S): Homo sapiens (Human) 
2020-08-04 | PXD015670 | Pride
Human embryonic stem cells  pluripotency  jarid2  prc2  proteomics  proteome 
ProteomicsProteomic solubility changes induced by pathogenic human tau/MAPT during aging in Drosophila.
Aging and other proteostatic stresses can lead to accumulation of insoluble protein aggregates that disrupt normal cell function. We would like to identify these proteins accumulating in insoluble proteins fractions and better understand the molecular mechanisms of how these proteins accumulate.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2024-09-30 | PXD045325 | Pride
Tau/mapt  proteome insolubility  drosophila melanogaster. 
ProteomicsProteomic changes induced by knockdown of UBA1 and of E2 ubiquitin-conjugating enzymes in human HEK293 cells (UBE2Q1, UBE2QL1, UBER, UBE2S).Proteomic changes induced by knockdown of UBA1 and of E2 ubiquitin-conjugating enzymes in human HEK293 cells (Ctrl, CtrlHS, E2poolRNAi, E2poolRNAiHS)
The project goal is to identify the proteins that are regulated with loss of the E2 enzymes. In this study E2poolRNAi, E2poolRNAiHS were investigated.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042341 | Pride
Uba1  e2 ubiquitin-conjugating enzymes  ubiquitin  human cells 
ProteomicsAcute Megakaryoblast Leukemia LC-MS/MS
Cord blood CD34 derived megakaryoblasts, cord blood CD34 derived megakaryoblasts gene modified with the CBFA2T3-GLIS2 fusion oncogene, and CBFA2T3-GLIS2 positive acute megakaryoblast leukemia patient samples underwent multiplexed mass spectrometry-based proteomic analysis.
ORGANISM(S): Homo sapiens (Human) 
2024-10-10 | PXD048474 | Pride
Human Acute leukemia Tmt Blood Megakaryoblast 
ProteomicsDeep Multilayer Tissue Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression, human data
The molecular networks underlying Alzheimer’s disease (AD) are not well-defined. We present temporal profiling of >14,000 proteins and >34,000 phosphosites at the asymptomatic and symptomatic stages of AD, deep proteomics analysis of transgenic mouse models.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-17 | MSV000096123 | MassIVE
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