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UnknownIceBear: an intuitive and versatile web application for research-data tracking from crystallization experiment to PDB deposition.
Not available
S-EPMC7869904 | biostudies-literature
TranscriptomicspiRNA-guided slicing of transposon transcripts enforces their transcriptional silencing via specifying the nuclear piRNA repertoire
PIWI-clade Argonaute proteins silence transposon expression in animal gonads. Their target specificity is defined by bound ~23-30nt piRNAs that are processed from single-stranded precursor transcripts via two distinct pathways. Primary piRNAs are defined by the endo-nuclease Zucchini, while biogenes...
ORGANISM(S): Drosophila melanogaster 
2015-08-31 | E-GEOD-71775 | biostudies-arrayexpress
TranscriptomicsBenign prostate epithelial cell gene expression after four weeks of treatment with daily transdermal DHT or placebo gel
Significant increases in serum DHT do not increase intraprostatic levels of DHT, PSA, prostate volume, or prostate epithelial cell androgen-regulated gene expression in healthy men. Changes in serum androgen concentrations are not necessarily mimicked within the prostate. Custom Agilent 44K whole hu...
ORGANISM(S): Homo sapiens 
2011-01-19 | E-GEOD-20317 | biostudies-arrayexpress
ProteomicsProteome analysis of the MO3.13 cell line from human oligodendrocytes
MO3.13 is an immortal human-human hybrid cell line that express phenotypic characteristics of primary oligodendrocytes. It was created by fusing a 6-thioguanine-resistant mutant of the human rhabdomyosarcoma RD (cancer of skeletal muscle) with adult human oligodendrocytes by a lectin-enhanced polyet...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083971 | MassIVE
ProteomicsDevelopmental mRNA clearance by PIWI-bound endo-siRNAs in Paramecium
The clearance of untranslated mRNAs by Argonaute proteins is essential for embryonic development in metazoans. However, it is currently unknown whether a similar process exists in unicellular eukaryotes. The ciliate Paramecium tetraurelia harbors a vast array of Argonaute proteins of the Piwi-clade ...
ORGANISM(S): Paramecium tetraurelia 
2023-05-10 | PXD038984 | Pride
Paramecium tetraurelia Piwi Mrna clearance Untranslated mrna Total protein < 25kda Sirnas 
UnknownEvolutionary Comparisons of Chelonid Alphaherpesvirus 5 (ChHV5) Genomes from Fibropapillomatosis-Afflicted Green (Chelonia mydas), Olive Ridley (Lepidochelys olivacea) and Kemp's Ridley (Lepidochelys kempii) Sea Turtles.
Not available
S-EPMC8465875 | biostudies-literature
ProteomicsDevelopment and validation of an ELISA to measure REG3E in canine blood
Regenerating islet-derived proteins (REG) are upregulated in people with sepsis, pancreatitis, and gastrointestinal diseases. One member of the REG family, namely REG3E, was recently identified in pancreatic tissue and plasma of dogs, with high expression in pancreatitis and sepsis. Our objective wa...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2024-06-10 | PXD046936 | Pride
Gastrointestinal Biomarker Sepsis Canine Pancreatitis Canis lupus familiaris Pancreas 
TranscriptomicsA novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity
Here we identify a Dicer-independent miRNA biogenesis pathway that employs the slicer catalytic activity of Argonaute2 (Ago2). To uncover Dicer-independent miRNAs, we sequenced small RNAs in wild type, maternal-zygotic dicer (MZdicer) and MZago2 mutants, using zebrafish as a model system. We find t...
ORGANISM(S): Danio rerio 
2010-07-01 | E-GEOD-21503 | biostudies-arrayexpress
TranscriptomicsElimination of mitochondrial DNA variants by nuclear genome transfer in human oocytes
Nuclear genome exchange between different oocytes results in efficient development and stem cell derivation 1 million cells was used for RNA extraction and labeling using the Illumina total prep RNA amplification kit. Parthenogenetic stem cell lines and embryonic stem cells
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-42077 | biostudies-arrayexpress
TranscriptomicsGene expression and H3K27 tri-methylation analysis of meristematic tissue (Me) and young leaves (Le) isolated by manual dissection of clv3-9 plants
This SuperSeries is composed of the following subset Series: GSE24464: Expression analysis of meristematic tissue (Me) and young leaves (Le) isolated by manual dissection of clv3-9 plants GSE24474: H3K27 tri-methylation analysis of meristematic tissue (Me) and young leaves (Le) isolated by manual di...
ORGANISM(S): Arabidopsis thaliana 
2011-04-20 | E-GEOD-24507 | biostudies-arrayexpress
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