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GenomicsPopulation Architecture using Genomics and Epidemiology (PAGE)

By relating hundreds of thousands of genotypes to only a few phenotypes, mostly in individuals of one ancestry, genome-wide association (GWA) studies are identifying a rapidly growing number of associations. The Population Architecture using Genomics and Epidemiology (PAGE) Study is designed to f...

phs000356.v1.p1 | EGA
ProteomicsTitle Page Cardiac Gene Therapy Rescues Diabetic Cardiomyopathy and Lowers Blood Glucose
Diabetic cardiomyopathy, an increasingly global epidemic and a major cause of heart failure with preserved ejection fraction (HFpEF), is associated with hyperglycemia, insulin resistance, and intra-cardiomyocyte calcium mishandling. Here we identify that, in db/db mice with type 2 diabetes induced H...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD044236 | Pride
Calcium handling Transverse-tubule microdomain Gene therapy Glucose uptake Diabetic cardiomyopathy 
ProteomicsThe proteomic analysis of Sclerotinia sclerotiorum
This study aims to identify proteins produced by S. sclerotiorum, thereby, increasing its current proteomic knowledge database. In summary, three biological replicates were pooled from one S. sclerotiorum culture and extracted mycelia proteins collected from solid culture were separated utilizing s...
ORGANISM(S): Sclerotinia Sclerotiorum (ncbitaxon:5180) 
2020-02-19 | MSV000084984 | MassIVE
GenomicsPopulation Architecture using Genomics and Epidemiology (PAGE): Causal Variants Across the Life Course (CALiCo): Atherosclerosis Risk in Communities (ARIC)

CALiCo ARIC
The Atherosclerosis Risk in Communities Study (ARIC), sponsored by the National Heart, Lung and Blood Institute (NHLBI), is a prospective epidemiologic study conducted in four U.S. communities. ARIC is designed to investigate the etiology and natural history of atheroscler...

phs000223.v1.p1 | EGA
GenomicsPopulation Architecture using Genomics and Epidemiology (PAGE): Causal Variants Across the Life Course (CALiCo): Coronary Artery Risk Development in Young Adults (CARDIA)

CALiCo CARDIA
The Coronary Artery Risk Development in Young Adults (CARDIA) Study is a study examining how heart disease develops in adults. It began in 1986 with a group of 5115 black and white men and women aged 18-30 years. The participants were selected so that there would be appr...

phs000236.v1.p1 | EGA
ProteomicsProteomic of Hydra vulgaris
This study aimed to identify the total proteome of Hydra vulgaris, a freshwater polyp, belongs to the cnidarians family with feature of not having a visual eye, while being sensitive to light. Proteins were identified using a combination of gel electrophoresis and data-independent nanoflow liquid c...
ORGANISM(S): Hydra vulgaris 
2022-02-28 | PXD005828 | Pride
Hydra vulgaris sds-gel-page nanolcmsms 
ProteomicsDenaturing mass photometry for rapid optimization of chemical protein-protein cross-linking reactions
Chemical cross-linking reactions (XL) are an important strategy for studying protein-protein interactions (PPIs), including low abundant sub-complexes, in structural biology. However, choosing XL reagents and conditions is laborious and mostly limited to analysis of protein assemblies that can be re...
ORGANISM(S): Escherichia coli 
2024-03-15 | PXD042549 | Pride
Mass photometry Cross-linking mass spectrometry 
GenomicResearch Program on Genes, Environment and Health (RPGEH)

The Kaiser Permanente Research Program on Genes, Environment, and Health (RPGEH) is a resource developed to facilitate research on genetic and environmental factors on common diseases and healthy aging. The RPGEH resource links biospecimens, health surveys, and comprehensive electronic medical re...

phs000788 | dbGaP
UnknownComprehensive functional testing in fibroblasts has strong utility to diagnose mitochondrial disease
Not available
S-SCDT-10_1038-S44321-026-00497-3 | biostudies-other
ProteomicsStructural basis of PROTAC-induced target ubiquitination mechanism - identification of BRD4 ubiquitination sites
Proteolysis Targeting Chimeras (PROTACs) hijack the ubiquitin proteasome system to ubiquitinate target proteins, targeting them for degradation by the proteasome. An understudied process that is essential to the PROTAC mechanism of action is ubiquitination of the target protein and ubiquitin (Ub) ch...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049043 | Pride
Protac Mz1 Ubiquitin Crl2vhl Brd4 
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